[关键词]
[摘要]
间充质干细胞(MSCs)是来源于中胚层的成体干细胞,体内分布广泛,可从骨髓、脂肪、牙髓、脐带/胎盘等组织中分离获取,具有高度的可增殖和分化潜能,较低的免疫原性,同时具有向炎症损伤部位微环境的趋向性,在疾病治疗方面可作为基因药物的载体实现精准治疗。癌症被认为是永远无法愈合的伤口,其组织微环境在损伤与修复中呈无休止的动态变化,MSCs在其中扮演了重要角色。利用MSCs具有的向肿瘤组织中归巢及定位的特点,对其进行抗肿瘤药物的基因工程改造可能在癌症的治疗上是一种新的策略。概述MSCs在癌症发生发展中的作用以及基因修饰MSCs治疗癌症的研究进展,旨在为临床使用基因修饰MSCs治疗癌症提供策略和见解。
[Key word]
[Abstract]
Mesenchymal stem cells (MSCs) is one of the adult stem cells, which is derived from mesoderm tissues. MSCs are widely distributed in tissues and organs, and can be isolated from bone marrow, fat, dental pulp, umbilical cord/placenta and other tissues. MSCs have high potential for proliferation and differentiation, low immunogenicity and a tendency to the microenvironment of inflammatory injury sites. MSCs hold clinical promise for the treatment of many diseases. Cancer is considered as a wound that can never be healed, and its tissue microenvironment changes endlessly during injury and repair, in which mesenchymal stem cells play an important role. Using the characteristics of mesenchymal stem cells to home and locate tumor tissue, genetic modification of MSCs with antitumor drug may be a new strategy in the treatment of cancer. This paper summarizes the role of mesenchymal stem cells in the occurrence and development of cancer and the research progress of gene modified mesenchymal stem cells in the treatment of cancer, in order to provide strategies and insights for the clinical use of gene modified mesenchymal stem cells in the treatment of cancer.
[中图分类号]
[基金项目]
北京市科技计划课题(Z211100002521006)