肌酐作为一种高效的肾功能生物标志物，已在临床上被广泛用于肾病的诊断以及对肾脏相关药物的评价。肌酐亦在其他系统疾病诊断、尿样中待检测物质的校准以及机能评定方面有一定作用。对肌酐的临床应用进行综述，并着重介绍了肌酐在肾病诊断，以及对肾脏相关药物的药效和不良反应评价的应用，并展望了肌酐在临床诊断、药物评价等方面的应用前景。

As a highly effective biomarker of kidney function, creatinine has been used clinically in the diagnosis of kidney disease and the evaluation of kidney-related drugs. It is also useful in the diagnosis of other systemic diseases, the calibration of substances to be tested in urine samples, and the assessment of function. This article reviews the clinical applications of creatinine and highlights the use of creatinine in the diagnosis of kidney disease and in the evaluation of the efficacy and adverse effects of kidneyrelated drugs, and concludes that creatinine has a promising future in clinical diagnosis and drug evaluation.

R965.3

国家自然科学基金重点资助项目（81830109）