目的 探讨复方丹参片联合阿司匹林治疗急性心肌梗死的临床疗效。方法 选取2019年7月—2021年6月在首都医科大学附属北京同仁医院就诊的急性心肌梗死患者80例，按照治疗方法将患者分为对照组和观察组，每组各40例。对照组口服阿司匹林肠溶片，首次剂量300 mg，持续剂量每日100 mg/次，1次/d。观察组在对照组基础上口服复方丹参片，3片/次，3次/d。两组连续治疗4周。观察两组患者的临床疗效，比较两组治疗前后的血清中内皮素-1（ET-1）和血管紧张素Ⅱ（Ang-Ⅱ）水平、心功能指标及血流动力学指标。结果 治疗后，观察组总有效率为92.5%，显著高于对照组的75.0%，组间有明显差异（P<0.05）。治疗后，两组的ET-1、Ang-Ⅱ水平明显降低，内皮依赖性血管舒张功能（FMD）明显升高（P<0.05）；治疗后，观察组的ET-1、Ang-Ⅱ水平显著低于对照组，FMD高于对照组，差异有统计学意义（P<0.05）。治疗后，两组的左心室压、主动脉压显著升高，肺循环阻力显著降低（P<0.05）；治疗后，观察组的左心室压、主动脉压显著高于对照组，肺循环阻力低于对照组，差异有统计学意义（P<0.05）。治疗后，两组的左室射血分数（LVEF）、每搏量（SV）均显著升高（P<0.05），且观察组升高更明显（P<0.05）。结论 复方丹参片能提高阿司匹林对急性心肌梗死的疗效，改善患者血管内皮功能和血流动力学，药物安全性良好。

Objective To investigate the clinical efficacy of Compound Danshen Tablets combined with aspirin in treatment of acute myocardial infarction. Methods Eighty patients with acute myocardial infarction who were treated in Beijing Tongren Hospital Affiliated to Capital Medical University from July 2019 to June 2021 were selected and divided into control group and observation group according to treatment methods, with 40 patients in each group. Patients in the control group were po administered with Aspirin Enteric-coated Tablets, the first dose was 300 mg, and the continuous dose was 100 mg/time, once daily, once a day. Patients in the observation group were po administered with Compound Danshen Tablets on the basis of control, three tablets/time, three times daily. Both groups were treated for 4 weeks. The clinical efficacy of the two groups was observed, and the serum levels of ET-1 and Ang-Ⅱ, cardiac function indexes, and hemodynamic indexes were compared before and after treatment. Results After treatment, the total effective rate of observation group was 92.5%, which was significantly higher than 75.0% of control group, and there was a significant difference between groups (P < 0.05). After treatment, the levels of ET-1 and Ang-Ⅱ in two groups were significantly decreased, and FMD was significantly increased (P < 0.05). After treatment, the levels of ET-1 and Ang-Ⅱ in the observation group were significantly lower than those in the control group, while FMD in the observation group was higher than those in the control group, with statistical significance (P < 0.05). After treatment, left ventricular pressure and aortic pressure in two groups were significantly increased, and pulmonary circulation resistance was significantly decreased (P < 0.05). After treatment, the left ventricular pressure and aortic pressure of the observation group were significantly higher than those of the control group, and the pulmonary circulation resistance was lower than that of the control group, with statistical significance (P < 0.05). After treatment, LVEF and SV in both groups were significantly increased (P < 0.05), and the increase was more obvious in the observation group (P < 0.05). Conclusion Compound Danshen Tablets can improve the efficacy of aspirin to acute myocardial infarction, improve vascular endothelial function and hemodynamics, and the drug safety is good.

R972