目的 探讨康复新液联合西地碘含片对慢性牙周炎患者的治疗效果及其对钙结合蛋白S100A12（S100A12）、乳铁蛋白（LF）水平的影响。方法 选取2018年6月—2020年6月南安市第二医院收治的106例慢性牙周炎患者为研究对象，根据治疗方法将两组患者分为对照组和观察组，每组各53例。对照组患者含服西地碘含片，1片/次，3～5次/d。观察组患者在对照组治疗的基础上含漱康复新液，10 mL/次，含漱3～5 min，3～5次/d，且两组患者均接受为期8周的治疗。观察两组患者的临床疗效，比较两组治疗前后的牙周健康指标及血清S100A12、LF水平。结果 治疗后，观察组总有效率为92.45%，显著高于对照组的73.58%（P<0.05）。治疗后，两组菌斑指数、牙齿附着丧失、牙齿松动度均显著降低（P<0.05）；且观察组菌斑指数、牙齿附着丧失、牙齿松动度均低于对照组（P<0.05）。治疗后，两组血清S100A12、LF水平均显著降低（P<0.05）；观察组血清S100A12、LF水平均低于对照组（P<0.05）。治疗后，两组生活质量评分显著升高，疼痛评分显著降低（P<0.05）；且观察组患者的生活质量评分高于对照组，疼痛评分低于对照组（P<0.05）。结论 康复新液联合西地碘含片对慢性牙周炎患者有良好的治疗作用，能够改善患者的牙周健康状况，降低S100A12、LF水平，改善患者的预后评分，治疗安全性良好。

Objective To study the therapeutic effect of Kangfuxin Liquid combined with Cydiodine Buccal Tablets in treatment of chronic periodontitis and its effect on S100A12 and lactoferrin(LF) levels. Methods A total of 106 patients with chronic periodontitis admitted to Nan'an Second Hospital from June 2018 to June 2020 were selected as the study subjects. According to the treatment methods, the two groups of patients were divided into the control group and the observation group, with 53 cases in each group. Patients in the control group were given Cydiodine Buccal Tablets, 1 tablet/time, 3-5 times/d. Patients in the observation group were treated with Kangfuxin Liquid, 10 mL/time, gargling for 3 to 5 min, 3-5 times/d, and both groups received treatment for 8 weeks. Observe the clinical efficacy of the two groups, and compare the periodontal health indicators, S100A12 and LF levels of the two groups before and after treatment. Results After treatment, the total effective rate of observation group was 92.45%, which was significantly higher than 73.58% of control group (P < 0.05). After treatment, plaque index, tooth attachment loss, and tooth loosening degree in two groups were significantly decreased (P < 0.05). And the plaque index, tooth attachment loss and tooth loosening degree in the observation group were lower than those in the control group (P < 0.05). After treatment, serum S100A12 and LF levels in two groups were significantly decreased (P < 0.05). The serum S100A12 and LF levels in observation group were lower than those in control group (P < 0.05). After treatment, quality of life score in two groups was significantly increased, pain score was significantly decreased (P < 0.05). The quality of life score of patients in the observation group was higher than that in the control group, and the pain score was lower than that in the control group (P < 0.05). Conclusion Kangfuxin Liquid combined with Cydiodine Buccal Tablets has a good therapeutic effect on patients with chronic periodontitis, which can improve the periodontal health of patients, reduce the levels of S100A12 and LF, improve the prognosis score of patients, and the treatment safety is good.

R988.2

泉州市科技计划项目（2018Z172）