目的 探讨桉柠蒎肠溶软胶囊联合哌拉西林他唑巴坦治疗支气管扩张症的临床疗效。方法 选取2017年2月—2019年3月吉林大学校医院收治的90例支气管扩张症患者作为研究对象，根据治疗方案将患者分为对照组和观察组，每组45例。对照组静脉滴注注射用哌拉西林/他唑巴坦钠，4.5 g加入250 mL生理盐水中，1次/d。观察组在对照组基础上口服桉柠蒎肠溶软胶囊，0.3 g/次，3次/d。两组均连续治疗10 d。观察两组患者的临床疗效和症状消失时间，同时比较两组治疗前后的血清白细胞介素-13（IL-13）、人巨噬细胞趋化蛋白-1（MCP-1）、肿瘤细胞坏死因子（TNF-α）的水平。结果 治疗后，观察组的总有效率为95.56%，显著高于对照组的80.00%，组间比较差异有统计学意义（P<0.05）。治疗后，观察组的退热时间、止咳时间、肺啰音消失时间、住院时间均短于对照组，差异有统计学意义（P<0.05）。治疗后，两组的IL-13水平明显升高，MCP-1、TNF-α水平明显降低（P<0.05）；治疗后，观察组的IL-13水平显著高于对照组，MCP-1、TNF-α水平低于对照组，差异有统计学意义（P<0.05）。结论 桉柠蒎肠溶软胶囊联合哌拉西林他唑巴坦可提高支气管扩张症的疗效，有效促进临床症状体征恢复，减轻炎症反应，改善肺功能，且安全性良好。

Objective To investigate the clinical efficacy of Eucalyptol, Limonene and Pinene Enteric Soft Capsules combined with piperacillin tazobactam in treatment of bronchiectasis. Methods A total of 90 patients with bronchiectasis admitted to Jilin University Hospital from February 2017 to March 2019 were selected as the research subjects. According to the treatment plan, the patients were divided into control group and observation group, with 45 patients in each group. Patients in the control group were iv administered with Piperacillin Sodium and Tazobactam Sodium for Injection, 4.5 g was added into 250 mL normal saline, once daily. Patients in the observation group were po administered with Eucalyptol, Limonene and Pinene Enteric Soft Capsules on the basis of control group, 0.3 g/ time, 3 times daily. Both groups were treated continuously for 10 days. Clinical efficacy and symptom disappearance time of two groups were observed. Serum levels of IL-13, MCP-1, and TNF-α before and after treatment were compared between two groups. Results After treatment, the total effective rate of the observation group was 95.56%, which was significantly higher than 80.00% of the control group, and the difference between groups was statistically significant (P < 0.05). After treatment, the fever abatement time, cough relief time, lung rales disappearance time, and hospitalization time in the observation group were all shorter than those in the control group, with statistical significance (P < 0.05). After treatment, the level of IL-13 was significantly increased, while the levels of MCP-1 and TNF-α were significantly decreased (P < 0.05). After treatment, the level of IL-13 in the observation group was significantly higher than that in the control group, while the levels of MCP-1 and TNF-α were lower than that in the control group, with statistical significance (P < 0.05). Conclusion The combination of Eucalyptol, Limonene and Pinene Enteric Soft Capsules and piperacillin tazobactam can improve the efficacy of bronchiectasis, effectively promote the recovery of clinical symptoms and signs, reduce inflammatory response, and improve lung function, with good safety.

R974

吉林省高教科研课题（JGJX2019C2）