目的 探讨荆防颗粒联合阿奇霉素治疗成人支原体肺炎的临床疗效。方法 选取2020年2月—2021年5月在临沂市人民医院治疗的成人支原体肺炎患者112例作为研究对象，按照治疗方式将患者分为对照组与观察组，每组各56例。对照组静脉滴注注射用阿奇霉素，0.5 g/次，1次/d。观察组在对照组基础上口服荆防颗粒，1袋/次，3次/d。两组均用药14 d。观察两组患者的临床疗效和临床症状消失时间，比较两组治疗前后的白细胞介素-6（IL-6）、肿瘤坏死因子（TNF-α）、降钙素原（PCT）的水平。结果 治疗后，观察组总有效率为91.07%，显著高于对照组的76.78%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，观察组患者体温恢复时间、咳嗽消失时间、肺部啰音消失时间、肺部阴影消失时间均短于对照组（P<0.05）。治疗后，两组患者的血清IL-6、IL-10、TNF-α水平均显著降低（P<0.05）；治疗后，观察组血清IL-6、IL-10、TNF-α水平显著低于对照组（P<0.05）。结论 荆防颗粒联合阿奇霉素治疗成人支原体肺炎的临床疗效确切，更有利于临床症状的改善，且安全性较高，值得临床推广应用。

Objective To investigate the clinical efficacy of Jingfang Granules combined with azithromycin in treatment of adult mycoplasma pneumonia. Methods A total of 112 adult patients with mycoplasma pneumonia hospitalized in the Linyi People's Hospital from February 2020 to May 2021 were selected as the research subjects. According to the treatment methods, the patients were divided into control group and observation group, with 56 patients in each group. Patients in the control group were iv administered with Azithromycin for Injection, 0.5 g/time, once daily. Patients in the observation group were po administered with Jingfang Granules, 1 bag/time, 3 times daily. Both groups were treated for 14 days. The clinical efficacy and symptom disappearance time of two groups were observed, and the levels of IL-6, TNF-α, and PCT before and after treatment were compared between two groups. Results After treatment, the total effective rate of the observation group was 91.07%, which was significantly higher than 76.78% of the control group, and the difference of total effective rate between two groups was statistically significant (P < 0.05). After treatment, the recovery time of body temperature, disappearance time of cough, disappearance time of lung rales, and disappearance time of lung shadow in observation group were all earlier than those in control group (P < 0.05). After treatment, the levels of serum IL-6, IL-10, and TNF-α in two groups were significantly decreased (P < 0.05). After treatment, the levels of serum IL-6, IL-10 and TNF-α in observation group were significantly lower than those in control group (P < 0.05). Conclusion Jingfang Granules combined with azithromycin in treatment of adult mycoplasma pneumonia has a definite clinical effect, is more conducive to the improvement of clinical symptoms, and the safety is high, worthy of clinical application.

R974

国家重点研发计划（2019YFC1711200）