斑马鱼繁殖力强、体积小、易饲养、发育快速、胚胎透明，与人类基因组同源性高，心脏结构和功能与哺乳类动物高度相似。基于斑马鱼模型的药物实验具有用药量少、周期短、指标易观察等优势，近年来斑马鱼模型在药物心血管安全性评价和心脏保护活性筛选领域得到了广泛应用。结合课题组前期研究及国内外文献，综述斑马鱼心功能评价应用进展，以期为斑马鱼在心血管药物安全性和活性评价中的应用提供参考。

As a model organism, zebrafish has many advantages such as high fecundity, small size, rapid development, transparency of embryos and high degree of genetic homology. Additionally, there is a high similarity of the heart structure and function between zebrafish and mammals. Recently, zebrafish has been widely used in the field of cardiovascular drug screening and cardioprotective activity tests, which is largely attributable to short period and low dosage of drug treatment. In this paper, we will review the progress of the heart function evaluation of zebrafish, based on the previous research and domestic and foreign literatures. In order to provide reference for the application of zebrafish in the evaluation of the cardiovascular safety and the activity of drugs.

R965.1

山东省优秀青年人才基金项目（ZR2020YQ60）；齐鲁工业大学（山东省科学院）科教产融合创新试点工程项目（2020KJCZD08）；齐鲁工业大学（山东省科学院）生物与生物化学ESI培育学科开放课题（ESIBBC202011）；济南市“高校20条”资助项目（2020GXRC053）