[关键词]
[摘要]
目的 探讨平消胶囊联合SOX方案治疗晚期胃癌的疗效。方法 选取2018年6月—2020年2月北京航天总医院收治的102例晚期胃癌患者作为研究对象,将所有患者按照治疗方法分为对照组与观察组,每组各51例。对照组患者给予SOX方案化疗,即口服替吉奥胶囊,初始剂量根据体表面积确定:体表面积<1.25 m2者40 mg/次,1.25~1.5 m2者50 mg/次,>1.5 m2者60 mg/次,均为2次/d,分别于早晚饭后服用,连续服用2周后停药1周;第1天奥沙利铂注射液,130 mg/m2,静脉滴注3 h。观察组在对照组治疗的基础上口服平消胶囊,5粒/次,3次/d,于化疗1周后开始服用。治疗4周后观察各指标变化情况。观察两组患者的临床疗效,同时比较两组的血清糖类抗原242(CA242)、糖类抗原125(CA125)、糖类抗原199(CA199)和癌胚抗原(CEA)水平,外周血转化生长因子-α(TGF-α)和腺苷酸活化蛋白激酶5(ARK5)水平;CD4+T淋巴细胞亚型Th17细胞、CD4+CD25+调节性T淋巴细胞(Treg)及Th17/Treg比值;观察并记录两组无进展生存期(PFS)和总生存期(OS)。结果 治疗后,观察组疾病控制率为73.47%,显著高于对照组的54.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组CA242、CA125、CA199、CEA水平显著低于治疗前(P<0.05),观察组CA242、CA125、CA199、CEA水平显著低于对照组(P<0.05)。治疗后,两组Th17、Treg、Th17/Treg均值低于治疗前(P<0.05);治疗后,观察组Th17、Treg、Th17/Treg值显著低于对照组(P<0.05)。治疗后,观察组患者PFS和OS为均长于对照组,差异有统计学意义(P<0.05)。治疗后,两组外周血TGF-α、ARK5水平均显著低于治疗前(P<0.05);且观察组治疗后外周血TGF-α、ARK5水平显著低于对照组(P<0.05)。结论 平消胶囊联合SOX方案治疗晚期胃癌疗效显著,可有效降低肿瘤标志物水平,抑制肿瘤生长,改善患者的免疫功能,延长生存期,改善预后,降低TGF-α、ARK5水平,抑制肿瘤转移,促进肿瘤细胞凋亡,同时还能降低毒副反应的发生率,安全性较高。
[Key word]
[Abstract]
Objective To investigate the effect of Pingxiao Capsules combined with SOX regimen in treatment of advanced gastric cancer. Methods A total of 102 patients with advanced gastric cancer admitted to Beijing Aerospace General Hospital from June 2018 to February 2020 were selected as the research subjects. All the patients were divided into control group and observation group according to treatment methods, with 51 patients in each group. Patients in the control group were received SOX regimen chemotherapy, patients were po administered with Tegafur, Gimeracil and Oteracil Potassium Capsules, and the initial dose was determined according to the body surface area: 40 mg/time in subjects with body surface area < 1.25 m2, 50 mg/time in subjects with body surface area 1.25 — 1.5 m2, and 60 mg/time in subjects with > 1.5 m2, twice daily, were given at night and after meals, respectively. After 2 weeks of continuous administration, the drug was stopped for 1 week. On day 1, Oxaliplatin Injection was given 130 mg/m2 intravenously for 3 h. Patients in the observation group were po administered with Pingxiao Capsules on the basis of control group, 5 grains/time, three times daily, and began to take them 1 week after chemotherapy. The changes of all indexes were observed after 4 weeks of treatment. Clinical efficacy of two groups was observed. The serum levels of CA242, CA125, CA199, CEA, and TGF-α, ARK5 levels in the peripheral blood, the ratio of Th17, Treg, Th17/Treg were compared between two group. And PFS and were observed and recorded in both groups. Results After treatment, the disease control rate of the observation group was 73.47%, significantly higher than 54.00% of the control group, and the difference between the two groups was statistically significant (P < 0.05). After treatment, the levels of CA242, CA125, CA199, and CEA in two groups were significantly lower than before treatment (P < 0.05), and the levels of CA242, CA125, CA199, and CEA in observation group were significantly lower than those in control group (P < 0.05). After treatment, the mean values of Th17, Treg, and Th17/Treg in two groups were lower than those before treatment (P < 0.05). After treatment, the values of Th17, Treg, and Th17/Treg in observation group were significantly lower than those in control group (P < 0.05). After treatment, PFS and OS of observation group were longer than control group, the difference was statistically significant (P < 0.05). After treatment, the levels of TGF-α and ARK5 in peripheral blood of two groups were significantly lower than before treatment (P < 0.05). The levels of TGF-α and ARK5 in peripheral blood of observation group were significantly lower than those of control group after treatment (P < 0.05). Conclusion Pingxiao Capsules combined with SOX regimen for advanced gastric cancer curative effect significantly, can effectively reduce the levels of tumor markers, inhibit tumor growth, improve the patient's immune function, prolong the survival period, improve prognosis, lower levels of TGF-α, ARK5, inhibiting tumor metastasis, promote tumor cell apoptosis, at the same time also can reduce the incidence rate of adverse reaction, with high security.
[中图分类号]
[基金项目]