目的 探讨丹参酮Ⅱ_A磺酸钠注射液联合奥拉西坦治疗卒中后认知障碍的疗效。方法 选择2019年2月—2020年9月重庆市九龙坡区人民医院收治的83例卒中后认知障碍患者作为研究对象，根据治疗方法将患者分为对照组（41例）和观察组（42例）。对照组患者口服奥拉西坦胶囊，800 mg/次，2次/d，连续治疗2周。观察组在对照组基础上静脉滴注丹参酮Ⅱ_A磺酸钠注射液，80 mg加入5%葡萄糖注射液250 mL中，1次/d，连续治疗2周。观察两组认知功能、记忆功能、生活能力、事件相关电位P300、炎性因子、氧化应激和不良反应差异。结果 两组治疗后MMSE、RBMT评分、BI指数、P300波幅、血清总抗氧化能力（T-AOC）水平均较治疗前显著增高，P300潜伏期、血清白细胞介素-6（IL-6）、C反应蛋白（CRP）、丙二醛（MDA）水平较治疗前显著降低（P<0.05）。治疗后，观察组MMSE、RBMT评分、BI指数、P300波幅、血清T-AOC水平显著高于对照组，P300潜伏期、IL-6、CRP、MDA水平显著低于对照组（P<0.05）。结论 丹参酮Ⅱ_A磺酸钠注射液联合奥拉西坦治疗卒中后认知障碍可提高认知、记忆功能和生活能力，安全性高，优于单纯奥拉西坦治疗。

Objective To investigate the efficacy of TanshinoneⅡ_A Sulfonate Injection combined with oxiracetam in treatment of cognitive impairment after stroke. Methods A total of 83 patients with post-stroke cognitive impairment admitted to Jiulongpo District People's Hospital, Chongqing from February 2019 to September 2020 were selected as the research subjects. According to the treatment methods, the patients were divided into control group (41 cases) and observation group (42 cases). Patients in the control group were po administered with Oxiracetam Capsules, 800 mg/time, twice daily for 2 weeks. Patients in the observation group were iv administered with Sulfotanshinone Sodium Injection on the basis of control group, 80 mg into 5% glucose injection 250 mL, once daily for 2 consecutive weeks. The differences in cognitive function, memory function, life ability, event-related potential P300, inflammatory factors, oxidative stress, and adverse reactions between two groups were observed. Results After treatment, MMSE, RBMT score, BI index, P300 amplitude, serum T-AOC levels were significantly increased in two groups, while P300 latency, serum levels of IL-6, CRP, and MDA were significantly decreased (P < 0.05). After treatment, MMSE, RBMT score, BI index, P300 amplitude and serum T-AOC level in observation group were significantly higher than those in control group, while P300 latency, IL-6, CRP, and MDA levels were significantly lower than those in control group (P < 0.05). Conclusions Sulfotanshinone Sodium Injection combined with oxiracetam in treatment of post-stroke cognitive impairment can improve cognitive, memory function and living ability, with high safety, which is better than olacetam alone.