[关键词]
[摘要]
目的 探讨孟鲁司特钠联合喜炎平注射液治疗小儿呼吸道合胞病毒感染肺炎的疗效观察。方法 选取2018年1月—2019年12月阜南县人民医院收治的90例小儿呼吸道合胞病毒感染肺炎患儿,按照治疗方法将患儿分为对照组和观察组,每组各45例。对照组喜炎平注射液与100 mL 5%葡萄糖溶液混合静脉滴注,5 mg/(kg·d),1次/d,疗程为2周。观察组在对照组治疗的基础上口服孟鲁司特钠片,10 mg/次,1次/d,持续治疗2周。对比两组患者临床治疗效果、临床症状改善时间、可溶性细胞间黏附分子1(sICAM-1)、半胱氨酰白三烯(CysLTs)水平及再次喘息发生率。结果 治疗后,观察组临床总有效率为95.56%,显著高于对照组的80.00%,差异具有统计学差异(P<0.05)。治疗后,观察组患者喘息改善时间,退烧时间和啰音消失时间均短于对照组,差异具有统计学差异(P<0.05)。治疗后,两组外周血sICAM-1、CysLTs水平均低于治疗前,且观察组外周血sICAM-1、CysLTs水平显著低于对照组,差异具有统计学差异(P<0.05)。治疗期间,观察组再次喘息发生率低于对照组,差异具有统计学差异(P<0.05)。结论 孟鲁司特钠联合喜炎平注射液治疗小儿呼吸道合胞病毒感染肺炎有较好的疗效,有助于降低sICAM-1和CysLTs水平,临床上值得继续推广。
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[Abstract]
Objective To observe the curative effect of montelukast sodium combined with Xiyanping Injection in treatment of children with respiratory syncytial virus pneumonia. Methods A total of 90 children with respiratory syncytial virus (RSV) infection pneumonia admitted to Funan County People's Hospital from January 2018 to December 2019 were selected and divided into control group and observation group according to treatment methods, with 45 cases in each group. Patients in the control group were iv administered with Xiyanping Injection, 5 mg/(kg·d), and 100 mL 5% glucose solution were mixed intravenously, once daily for 2 weeks. Patients in the observation group were po administered with Montelukast Sodium Tablets on the basis of control group, 10 mg/time, once daily for 2 weeks. The clinical treatment effect, clinical symptom improvement time, the levels of SICAM-1, CYSLTs and the incidence of re-wheezing were compared between two groups. Results After treatment, the total clinical effective rate of the observation group was 95.56%, significantly higher than that of the control group (80.00%), and the difference was statistically significant (P < 0.05). After treatment, the improved wheezing time, fever reduction time, and rale disappearance time in the observation group were shorter than those in the control group, with statistical differences (P < 0.05). After treatment, the levels of sICAM-1, CysLTs in peripheral blood of two groups were lower than before treatment, and the levels of sICAM-1 and CysLTs in peripheral blood of the observation group were significantly lower than the control group, the difference was statistically significant (P < 0.05). During treatment, the incidence of second wheezing in the observation group was lower than that in the control group, with statistical difference (P < 0.05). Conclusion Montelukast sodium combined with Xiyanping Injection has a good efficacy in treatment of respiratory syncytial virus pneumonia in children, which helps to reduce the levels of SICAM-1 and CYSLTs, and is worthy of further promotion in clinical practice.
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[基金项目]
安徽省卫生健康委员会科研计划项目(2019SEY008)