[关键词]
[摘要]
目的 观察脉络舒通丸治疗下肢血栓性浅静脉炎的临床疗效。方法 选取2018年1月—2020年12月安徽省第二人民医院收治的64例下肢血栓性浅静脉炎患者,根据治疗方案将患者分为对照组和观察组,每组32例。对照组采用基础治疗,观察组在对照组治疗方案基础上口服脉络舒通丸,12 g/次,3次/d。两组患者疗程均为2周。观察两组患者的临床疗效,同时比较两组治疗前后的临床症状评分、炎症因子及血液流变学指标水平。结果 治疗后,观察组总有效率为93.75%,显著高于对照组的84.38%,差异具有统计学意义(P<0.05)。治疗后,两组患者皮肤红肿、患肢肿胀、患肢疼痛以及筋脉条索评分均显著降低,差异具有统计学意义(P<0.05);观察组患者临床体征情况优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平均显著下降,差异具有统计学意义(P<0.05)。治疗后,观察组患者IL-6和TNF-α水平显著低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者血液流变学指标均显著改善,差异具有统计学意义(P<0.05);观察组血液流变学指标显著优于对照组,差异具有统计学意义(P<0.05)。结论 在常规治疗下肢血栓性浅静脉炎的基础上加用脉络舒通丸能显著增加疗效,值得临床推广。
[Key word]
[Abstract]
Objective To observe the clinical effect of Mailuo Shutong Pills in treating superficial thrombophlebitis of lower limbs. Methods Sixty-four patients with lower extremity thrombotic superficial phlebitis admitted from January 2018 to December 2020 in Anhui No. 2 Provincial People's Hospital were selected and divided into control group and observation group according to treatment plan, with 32 cases in each group. Patients in the control group were treated with basic treatment, and the observation group were po administered with Mailuo Shutong Pills on the basis of control group, 12 g/time, three times daily. The course of treatment for both groups was 2 weeks. The clinical efficacy of two groups was observed, and the clinical symptom scores, inflammatory factors, and hemorheological indexes of two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 93.75%, significantly higher than 84.38% of the control group, and the difference was statistically significant (P < 0.05). After treatment, skin redness, swelling, pain, and tendon cord score in two groups were significantly decreased, with statistical significance (P < 0.05). The clinical signs of observation group were better than control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of IL-6 and TNF-α in two groups were significantly decreased, with statistical significance (P < 0.05). After treatment, the levels of IL-6 and TNF-α in observation group were significantly lower than those in control group, the difference was statistically significant (P < 0.05). After treatment, hemorheology indexes in two groups were significantly improved, with statistical significance (P < 0.05). The hemorheological indexes in the observation group were significantly better than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion Adding Mailuo Shutong Pills on the basis of conventional treatment for superficial thrombophlebitis of lower limbs can significantly increase the curative effect and is worthy of clinical promotion.
[中图分类号]
R972
[基金项目]