[关键词]
[摘要]
氧化苦参碱对心脏具有正性肌力、负性频率和负性自律性的作用,因此具有广谱抗心律失常作用。氧化苦参碱对冠脉狭窄缺血、缺血再灌注以及异丙肾上腺素、阿霉素、感染和免疫引起的心肌损伤都有保护作用,并能阻滞心肌肥大和纤维化发生发展。氧化苦参碱心脏保护作用的基本机制是其抗氧化、抗炎和免疫抑制以及抑制盐皮质激素(醛固酮)受体的表达,产生心肌保护作用。即通过激活Nrf2/HO-1信号通路和抑制转化生长因子(TGF)-β1及I型TGF-β1受体的表达,从而抑制下游的JAK/STAT、MAPK/Smad2/3和Notch的信号通路的机制,减少心肌细胞凋亡,减轻心肌损伤和抑制胶原合成,产生抑制心肌肥大和纤维化的作用。
[Key word]
[Abstract]
Oxymatrine has positive inotropic action, negative chronotropic action, and negative automatic action, so it possesses a braod-spectrum antiarrhythmic effect. Oxymatrine has the protective actions against myocardial injuries induced by coronary artery stricture-induced ischemia, ischemia/reperfusion, isoproterenol, adriamycin, infection and immunization, Oxymatrine can block to occurrence and development of myocardial hypertrophy and fibrosis. The basic mechanisms of cardioprotective effect of oxymatrine are antioxidation, anti-inflammation, immunodepression, and down-regulating the expression of mineralocorticoid (aldosterone) receptor, thus activating Nrf2/HO-1 pathway, and inhibiting the expression of TGF-β1 and its I type receptor, therefore blocking backward signaling pathways of JNK/STAT, MAPK/Smad2/3, and Notch, to decrease myocardial apoptosis, and prevent myocardial injury and collagen synthesis, so to express the attenuating effects of myocardial hypertrophy and fibrosis.
[中图分类号]
R285.5
[基金项目]