莱菔硫烷是一种富含于十字花科植物的天然活性成分，对于脂肪肝具有良好的防治作用。药理研究发现莱菔硫烷通过减少脂肪积累、缓解线粒体功能障碍以及恢复氧化平衡缓解饮食因素引起的代谢相关脂肪性肝病；通过加速体内乙醛的代谢、减轻细胞内的氧化应激、修复肠道屏障功能缓解酒精性脂肪肝。莱菔硫烷缓解代谢相关脂肪性肝病的作用机制研究较多，并体现出明显的优势，综述其调节脂肪肝的药理作用研究进展，以期为新药研发提供理论依据。

Sulforaphane is a natural active ingredient rich in cruciferous plants and has a good preventive effect on fatty liver disease (FLD). Pharmacological studies have found that SFN reduces fat accumulation, relieves mitochondrial dysfunction, and restores oxidative balance to alleviate metabolic-associated fatty liver disease (MAFLD) caused by dietary factors; accelerates the metabolism of acetaldehyde in the body, reduces intracellular oxidative stress, and repairs the intestinal barrier function to relieve alcoholic liver disease. There are many studies on the mechanism of SFN in relieving MAFLD, and it has shown obvious advantages. The research progress of its pharmacological effect on regulating FLD is reviewed in order to provide a theoretical basis for the research and development of new drugs.

R285.5

国家自然科学基金面上项目（81573135）；黑龙江中医药大学优秀青年学术带头人支持计划项目