[关键词]
[摘要]
目的 探讨心悦胶囊联合比索洛尔治疗冠心病心绞痛的疗效及其对血液流变学的影响。方法 选取2019年3月-2020年3月在安阳市第六人民医院就诊的100例冠心病心绞痛患者作为研究对象,按照治疗方法将患者分为对照组和观察组,每组各50例。对照组患者口服富马酸比索洛尔片,5 mg/次,1次/d。观察组在对照组的基础上口服心悦胶囊,0.6 g/次,3次/d。两组均连续治疗1个月。观察两组患者的临床疗效,比较两组患者心绞痛症状(发作频率、持续时间)、视觉模拟评分(VAS);检测两组治疗前后的纤维蛋白原、全血黏度、D-二聚体水平及左室射血分数(LVEF)、心输出量(CO)。记录药物相关不良反应的情况。结果 治疗后,观察组患者总有效率为94.00%,显著高于对照组的80.00%,组间比较差异有统计学意义(P<0.05)。治疗后,两组的发作频率、持续时间和VAS评分均显著降低(P<0.05);观察组的发作频率、持续时间及VAS评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的LVEF、CO均明显升高(P<0.05);且观察组升高更明显(P<0.05)。治疗后,两组的纤维蛋白原、全血黏度、D-二聚体均明显降低(P<0.05);治疗后,观察组的纤维蛋白原、全血黏度、D-二聚体均低于对照组,差异有统计学意义(P<0.05)。两组的药物不良反应的发生率无明显差异。结论 心悦胶囊联合比索洛尔治疗冠心病心绞痛的疗效确切,能有效减轻症状和疼痛程度,改善血液流变学和心功能,且安全性较好。
[Key word]
[Abstract]
Objective To investigate the effect of Xinyue Capsules combined with bisoprolol in treatment of coronary heart disease angina pectoris and its effect on hemorheology. Methods A total of 100 patients with coronary heart disease and angina pectoris treated in the Anyang People's Hospital NO.6 from March 2019 to March 2020 were selected as the research subjects. According to the treatment methods, the patients were divided into control group and observation group, with 50 patients in each group. Patients in the control group were po administered with Bisoprolol Fumarate Tablets, 5 mg/time, once daily. Patients in the observation group were po administered with Xinyue Capsules, 0.6 g/time, three times daily. Both groups were treated continuously for one month. Clinical efficacy of two groups was observed, angina symptoms (attack frequency, duration) and VAS score were compared between two groups. The levels of fibrinogen, whole blood viscosity, D-dimer, and left ventricular ejection fraction (LVEF) and cardiac output (CO) in two groups were measured before and after treatment in two groups. Drug-related adverse reactions were recorded. Results After treatment, the total effective rate of observation group was 94.00%, significantly higher than that of control group (80.00%), and the difference between groups was statistically significant (P<0.05). After treatment, the attack frequency, duration and VAS score in two groups were significantly decreased (P<0.05). The frequency, duration and VAS score of the observation group were lower than those of the control group, and the difference was statistically significant (P<0.05). After treatment, LVEF and CO in two groups were significantly increased (P<0.05). In the observation group, the increase was more significant (P<0.05). After treatment, the fibrinogen, whole blood viscosity and D-dimer in two groups were significantly decreased (P<0.05). After treatment, the fibrinogen, whole blood viscosity and D-dimer in the observation group were lower than those in the control group, with statistical significance (P<0.05). There was no significant difference in the incidence of adverse drug reactions between two groups. Conclusion Xinyue Capsules combined with bisoprolol has definite efficacy in treatment of coronary heart disease angina pectoris, which can effectively reduce symptoms and pain degree, improve hemorheology and cardiac function, and has good safety.
[中图分类号]
R972
[基金项目]
河南省医学科技项目(2018020594)