[关键词]
[摘要]
催产素是由下丘脑合成的一种神经肽,在分娩时促进子宫平滑肌的收缩,但其在社交行为、焦虑、情绪、疼痛调节等方面也起重要作用。催产素通过外周和中枢多种药理机制参与镇痛和抗焦虑的作用已得到广泛研究。综述了近年来催产素与疼痛和焦虑相关的基础和临床研究进展,总结相关作用机制,并进一步探讨了催产素参与的镇痛和抗焦虑间的联系,有助于深入了解其多重作用机制,为这些疾病的治疗及新药研发提供依据。
[Key word]
[Abstract]
Oxytocin is neuropeptide synthesized by the hypothalamus, of which classical physiological function is to promote contraction of smooth, but recent studies have demonstrated that oxytocin plays an important role in social behavior, anxiety, mood and pain. The effects of oxytocin on analgesia and anti-anxiety by acting in the central and peripheral nervous system have been extensively studied. This article reviewed recent advances in research on basic and clinical works, summarized corresponding mechanisms and discussed the relationships between analgesia and anti-anxiety induced by oxytocin, which may help understand the multiple function of oxytocin and provide insights for the application and development of new drug.
[中图分类号]
R984
[基金项目]
上海市科委医学引导类项目(19401930500);上海市卫健委面上项目(201740072)