目的运用网状Meta分析的方法评价经典名方及中成药治疗慢性咽炎的疗效与安全性。方法检索中国知网、维普、万方、PubMed、Web of Science数据库中从建库至2020年10月份的中成药及经典名方治疗慢性咽炎的临床随机平行对照试验（RCT）。根据纳入标准筛选并提取相关数据，运用Review Manger 5.3软件进行纳入研究筛选流程图的制作以及质量评价，运用Stata14.0软件进行网状Meta分析。结果最终纳入27项RCT研究，涉及7个经典名方，9个中成药，共3 924个病例。网状Meta分析结果显示：临床总有效率方面，麦门冬汤>新癀片>十味龙胆花颗粒>补中益气汤>金莲清热泡腾片>黄连阿胶汤>金嗓利咽丸>口炎清颗粒>半夏散及汤>养阴清肺汤>清开灵滴丸>会厌逐瘀汤>一清胶囊>双黄连>猪肤汤>蓝芩口服液；咽痛、咽养改善情况方面，口炎清颗粒>会厌逐瘀汤；干咳改善情况方面，会厌逐瘀汤>口炎清颗粒；不良反应发生率方面，清开灵滴丸>蓝芩口服液>金莲清热泡腾片；复发率方面，猪肤汤>会厌逐瘀汤>双黄连>清开灵滴丸。结论经典名方及中成药治疗慢性咽炎疗效显著，不良反应发生率及复发率低，可明显改善慢性咽炎患者咽痛、咽痒、干咳等症状，其中麦门冬汤在慢性咽炎的治疗上有巨大的潜力。

Objective Network Meta-analysis was used to evaluate the efficacy and safety of Chinese patent medicine and classic prescription in treatment of chronic pharyngitis. Methods The RCT research of Chinese patent medicine and Classic prescription in treatment of chronic pharyngitis from the database of CNKI, VIP, WanFang, PubMed, Embase and Web of Science from construction to October 2020 was searched. Relevant data were screened and extracted according to the inclusion criteria. Use Review Manger 5.3 software to make flow chart and analyze included studies quality bias. Stata14.0 software was used for the comparison of Network Meta-analysis. Results Finally, 27 RCT studies were included, including 7 classic prescriptions and 9 Chinese patent medicines, involving a total of 3 924 cases. Network Meta-analysis results showed that the total clinical effective rate was Maimendong Decoction > Xinhuang Tablets > Shiwei Longdanhua Granules > Buzhong Yiqi Decoction > Jinlian Qingre Effervescent Tablets > Huanglian Ejiao Decoction > Jinsang Liyan Pills > Kouyanqing Granules > Banxia Sanji Decoction > Yangyin Qingfei Decoction > Qingkailing Dripping Pills > Huiyan Zhuyu Decoction > Yiqing Capsule > Shuanghuanglian > Zhufu Decoction > Lanqin Oral Liquid. In terms of improvement of pharyngalgia and pharyngeal nutrition, Kouyanqing Granules > Huiyan Zhuyu Decoction. In terms of improvement of dry cough, Huiyan Zhuyu Decoction > Kouyanqing Granules. The incidence of adverse reactions was Qingkailing Dropping Pills > Lanqin Oral Liquid > Jinlian Qingre Effervescent Tablets, the recurrence rate was Zhufu Decoction > Huiyan Zhuyu Decoction > Shuanghuanglian > Qingkailing Dropping Pills. In terms of recurrence rate, Zhufu Decoction > Huiyan Zhuyu Decoction > Shuanghuanglian > Qingkailing Dripping Pills. Conclusion Classic prescription and Chinese patent medicine have significant effect on chronic pharyngitis. The incidence of adverse reactions and recurrence rate is low. Classic prescription and Chinese patent medicine can significantly improve the symptoms of pharyngeal pain, pharyngeal itching and dry cough in patients with chronic pharyngitis. Maimendong Decoction has great potential in treatment of chronic pharyngitis.

R974

国家自然科学基金面上项目（81773997）；天津市研究生科研创新项目（2019YJSS199）；天津中医药大学研究生科研创新项目（YJSKC-20191025）；泰山学者工程专项经费项目（ts201511107）