[关键词]
[摘要]
目的探讨羚羊角颗粒联合奥卡西平治疗儿童癫痫的疗效。方法选取2017年5月-2019年5月在潍坊市妇幼保健院儿科住院治疗的46例癫痫患儿为研究对象,根据随机数字法将患儿分为对照组(23例)和观察组(23例)。对照组患儿口服奥卡西平片30 mg/(kg·d),1次/d。观察组在对照组的基础上口服羚羊角颗粒,5 g/次,2次/d。两组均连续服用15 d。观察两组患者的临床疗效,同时比较两组治疗前后的脑电图波段占比情况及血清白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-9(MMP-9)、高迁移率蛋白1(HMGB1)水平。结果治疗后,对照组总有效率为69.57%,显著低于观察组的95.66%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组癫痫发作频率和持续时间均显著降低(P<0.05);治疗后,观察组发作频率和持续时间显著低于对照组(P<0.05)。治疗后,两组患者脑电图波段δ波、θ波百分比显著降低,而α波、β波百分比显著升高(P<0.05);观察组患者脑电图波段δ波、θ波百分比低于对照组,α波、β波百分比高于对照组(P<0.05)。治疗后,两组IL-6、TNF-α、MMP-9、HMGB1水平均显著降低(P<0.05);且观察组患者的IL-6、TNF-α、MMP-9、HMGB1水平显著低于对照组(P<0.05)。治疗期间,观察组患者的不良反应总发生率8.69%,低于对照组的34.78%(P<0.05)。结论羚羊角颗粒与奥卡西平联合治疗癫痫患儿临床的效果显著,可明显控制癫痫发作,减少脑电图中痫性放电,患儿智力水平和生活质量得到提高,在临床上值得推广。
[Key word]
[Abstract]
Objective To investigate the efficacy of Lingyangjiao Granules combined with oxcarbazepine in treatment of pediatric epilepsy. Methods A total of 46 children with epilepsy who were hospitalized in the W.F. Maternal and Child Health Hospital from May 2017 to May 2019 were selected as the research subjects. According to random number method, the children were divided into control group (23 cases) and observation group (23 cases). Children in the control group were po administered with Oxcarbazepine Tablets 30 mg/(kg·d), once daily. Children in the observation group were po administered with Lingyangjiao Granules on the basis of control group, 5 g/time, twice daily. Both groups were treated for 15 d continuously. The clinical efficacy of two groups was observed, and the ratio of EEG bands and serum levels of IL-6, TNF-α, MMP-9, and HMGB1 before and after treatment were compared. Results After treatment, the total effective rate of the control group was 69.57%, significantly lower than 95.66% of the observation group, and the difference between two groups was statistically significant (P < 0.05). After treatment, the frequency and duration of seizures in two groups were significantly decreased (P < 0.05). After treatment, the frequency and duration of seizure in observation group were significantly lower than those in control group (P < 0.05). After treatment, the percentages of δ wave and θ wave in EEG band were significantly decreased, while the percentages of α wave and β wave were significantly increased (P < 0.05). The percentage of δ wave and θ wave in EEG band in observation group was lower than that in control group, and the percentage of α wave and β wave in observation group was higher than that in control group (P < 0.05). After treatment, the levels of IL-6, TNF-α, MMP-9 and HMGB1 in two groups were significantly decreased (P < 0.05). The levels of IL-6, TNF-α, MMP-9 and HMGB1 in observation group were significantly lower than those in control group (P < 0.05). During treatment, the total incidence of ADR in observation group was 8.69%, which was lower than 34.78% in control group (P < 0.05). Conclusion Lingyangjiao Granules combined with oxcarbazepine has a significant clinical effect in treatment of children with epilepsy, which can significantly control epileptic seizures, reduce epileptic discharge in electroencephalogram, and improve the intelligence level and quality of life of children, which is worthy of promotion in clinical practice.
[中图分类号]
R971
[基金项目]