[关键词]
[摘要]
目的探讨益中生血片联合琥珀酸亚铁片治疗重度缺铁性贫血的临床疗效。方法选择2019年1月-2020年1月于河北北方学院附属第一医院就诊的120例重度缺铁性贫血患者作为研究对象,采用随机数字表法将患者分为对照组和观察组,每组60例。对照组患者餐后服用琥珀酸亚铁片,1片/次,3次/d。观察组在对照组基础上餐后服用益中生血片,2片/次,3次/d,4周为1个疗程,两组患者均治疗1个疗程。观察两组患者的临床疗效,同时比较两组治疗前后的中医证候积分,外周血红细胞(RBC)、血红蛋白(Hb)、平均红细胞体积(MCV)、平均红细胞血红蛋白量(MCH)、红细胞平均血红蛋白浓度(MCHC)、网织红细胞血红蛋白(Ret-He)含量,以及血清铁离子(Fe)和血清铁蛋白(SF)水平。结果治疗后,对照组和观察组的总有效率分别为83.33%、95.00%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,两组患者中医证候积分均降低(P<0.05),且观察组明显低于对照组(P<0.05)。治疗后,两组患者RBC、Hb、MCV、MCH、MCHC、Ret-He水平均显著升高(P<0.05);且观察组外周血象水平明显高于对照组(P<0.05)。治疗后,两组患者血清Fe、SF水平均升高(P<0.05),且观察组血清Fe、SF水平明显高于对照组(P<0.05)。结论益中生血片联合琥珀酸亚铁片对重度缺铁性贫血患者疗效较好,可有效改善患者外周血象,提高网织红细胞血红蛋白含量并改善铁代谢水平。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Yizhong Shengxue Tablets combined with Ferrous Succinate Tablets in treatment of severe iron deficiency anemia. Methods A total of 120 patients with severe iron deficiency anemia who were treated in the First Affiliated Hospital of Hebei North University from January 2019 to January 2020 were selected as the research subjects. The patients were divided into control group and observation group by random number table method, with 60 cases in each group. Patients in the control group were po administered with Ferrous Succinate Tablets after meal, 1 tablet/time, three times daily. Patients in the observation group were po administered with Yizhong Shengxue Tablets on the basis of control group after meal, 2 tablets/ time, three times daily, four weeks as a course of treatment. Patients in both groups were treated for a course of treatment. To observe the clinical efficacy of two groups, and TCM syndrome integral, the levels of peripheral blood RBC, Hb, MCV, MCH, MCHC, Ret-He, and serum iron and ferritin before and after treatment were compared. Results After treatment, the total effective rate of the control group and the observation group was 83.33% and 95.00%, respectively, and the difference of total effective rate between two groups was statistically significant (P < 0.05). After treatment, TCM syndrome scores in two groups were decreased (P < 0.05), and observation group was significantly lower than control group (P < 0.05). After treatment, the levels of RBC, Hb, MCV, MCH, MCHC and Ret-He in two groups were significantly increased (P < 0.05). And the levels of peripheral blood in observation group was significantly higher than that in control group (P < 0.05). After treatment, the levels of serum Fe and SF in two groups were increased (P < 0.05), and the levels of serum Fe and SF in observation group were significantly higher than those in control group (P < 0.05). Conclusion Yizhong Shengxue Tablets combined with Ferrous Succinate Tablets has a good effect on patients with severe iron deficiency anemia, which can effectively improve peripheral blood image, increase reticulocyte hemoglobin content and improve iron metabolism level.
[中图分类号]
R973
[基金项目]
河北省医学科学研究重点课题计划(2017804);张家口市2019年度市级科技计划项目(1921135H)