目的 观察香砂平胃颗粒联合伊托必利治疗功能性消化不良的临床效果。方法 选取2018年6月-2019年6月在重庆市巴南区人民医院进行治疗的功能性消化不良患者83例作为研究对象，根据治疗方法将患者分为对照组（41例）和观察组（42例）。对照组患者口服盐酸伊托必利分散片，50 mg/次，3次/d；观察组在对照组的基础上口服香砂平胃颗粒，1袋/次，2次/d。两组患者均治疗30 d。观察两组患者的临床疗效，同时比较两组治疗前后的胃肠激素水平、电节律情况、生活质量和临床积分。结果 治疗后，观察组总有效率为97.6%，显著高于对照组的65.8%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清胃动素（MTL）、胃泌素（GAS）和P物质（SP）水平均明显升高（P<0.05），且观察组患者胃肠激素水平显著高于对照组（P<0.05）。治疗后，两组患者的胃体、胃大弯、胃小弯、胃窦电节律均明显降低（P<0.05）；观察组患者电节律显著低于对照组（P<0.05）。治疗后，两组患者SF-36评分均显著提高（P<0.05），且观察组SF-36评分显著高于对照组（P<0.05）。治疗后，两组患者在饱胀感、早饱、上腹痛、胃灼热感评分及总分均显著降低（P<0.05）；且观察组临床症状评分显著低于对照组（P<0.05）。结论 香砂平胃颗粒联合伊托必利治疗功能性消化不良患者疗效显著，能改善临床症状，提高患者胃动力功能和生活质量，值得推广使用。

Objective To observe the clinical effect of Xiangsha Pingwei Granules combined with itopride in treatment of functional dyspepsia. Methods A total of 83 patients with functional dyspepsia treated in People's Hospital of Chongqing Banan District from June 2018 to June 2019 were selected as the research subjects, and the patients were divided into control group (41 cases) and observation group (42 cases) according to the treatment methods. Patients in the control group were po administered with Itopride Hydrochloride Dispersible Tablets, 50 mg/time, three times daily. Patients in the observation group were po administered with Xiangsha Pingwei Granules on the basis of control group, 1 bag/time, twice daily. Patients in two groups were treated for 30 d. The clinical efficacy of two groups was observed, and the levels of gastrointestinal hormones, electrical rhythm, quality of life and clinical scores of the two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 97.6%, which was significantly higher than 65.8% of the control group, and the difference between two groups was statistically significant (P < 0.05). After treatment, the serum levels of MTL, GAS, SP in two groups were significantly increased (P < 0.05), and the gastrointestinal hormone level in observation group was significantly higher than those in control group (P < 0.05). After treatment, the gastric body, greater curvature, lesser curvature, and antrum of the stomach electric rhythm in two groups were significantly decreased (P < 0.05), and the electric rhythm in observation group was significantly lower than that in control group (P < 0.05). After treatment, the SF-36 score in two groups was significantly increased (P < 0.05), and the observation group was significantly higher than the control group (P < 0.05). After treatment, the scores of feeling of fullness, early satiety, epigastric pain, heartburn and total scores in two groups were significantly decreased (P < 0.05), and the clinical symptom score of observation group was significantly lower than those of control group (P < 0.05). Conclusion Xiangsha Pingwei Granules combined with itopride has significant efficacy in treatment of patients with functional dyspepsia, which can improve clinical symptoms, improve gastric motility function and quality of life of patients, and is worthy of promotion.

R975

重庆市卫计委医学科研课题（2017ZDXM006）