新型α-葡萄糖苷酶抑制剂筛选及药理作用研究进展

阎成炟，郭崇真，林建阳; YAN Chengda; GUO Chongzhen; LIN Jianyang

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2025年6月13日 19:32 星期五

首页 > 过刊浏览>2021年第44卷第2期 >2021,44(2):440-445. DOI:10.7501/j.issn.1674-6376.2021.02.029

新型α-葡萄糖苷酶抑制剂筛选及药理作用研究进展

阎成炟
阎成炟
中国医科大学附属第一医院药学部, 辽宁沈阳 110001;中国医科大学药学院, 辽宁沈阳 110122
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郭崇真
郭崇真
中国医科大学附属第一医院药学部, 辽宁沈阳 110001;中国医科大学药学院, 辽宁沈阳 110122
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林建阳
林建阳
中国医科大学附属第一医院药学部, 辽宁沈阳 110001;中国医科大学药学院, 辽宁沈阳 110122
通讯作者.
Email: linjianyangydyy@126.com
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Research progress of screen and pharmacological effect for novel α-glucosidase

YAN Chengda
YAN Chengda
Department of Pharmacy, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;College of Pharmaceutical Science, China Medical University, Shenyang 110122, China
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GUO Chongzhen
GUO Chongzhen
Department of Pharmacy, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;College of Pharmaceutical Science, China Medical University, Shenyang 110122, China
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LIN Jianyang
LIN Jianyang
Department of Pharmacy, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;College of Pharmaceutical Science, China Medical University, Shenyang 110122, China
Contact Author.
Email: linjianyangydyy@126.com
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发布日期：2021-02-03

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[关键词]

α-葡萄糖苷酶抑制剂 ; 2型糖尿病 ; 作用机制 ; 药理作用 ; 抗病毒 ; 抗溶酶体堆积病

[摘要]

α-葡萄糖苷酶抑制剂能有效降低餐后血糖，为临床一线降糖用药之一。近年来报道了大量新化合物作为α-葡萄糖苷酶抑制剂，不仅可以起到降糖的作用，而且还具有抗溶酶体堆积病、抗病毒、抗菌和抗癌的药效。α-葡萄糖苷酶抑制剂新型化合物按照产出途径主要有微生物代谢产物、天然产物与化学合成产物。就近年来开发的多种类型的α-葡萄糖苷酶抑制剂及其抗癌、抗病毒和抗溶酶体堆积病作用进行了综述，旨在为α-葡萄糖苷酶抑制剂或临床前候选药物提供更好的研究方向。

[Key word]

Alpha-glucosidase ; type 2 diabetes mellitus ; mechanism of action ; pharmacological effect ; research progress ; antiviral ; anti-lysosomal storage disorders

[Abstract]

Alpha-glucosidase inhibitor is one of the first-line antidiabetic medication which could reduce postprandial blood glucose effectively. In recent years, a substantial number of new compounds have been reported as alpha-glucosidase inhibitors, have multiple physiological effects including hypoglycemic effects, anticancer, antiviral, and anti-lysosomal storage disorders effect. The main types of new alpha-glucosidase inhibitor are microbial metabolites, natural products and chemically synthesized products. This review presents the various types of alpha-glucosidase inhibitors developed in recent years and its pharmacological effects, aimed to provide guidance to alpha-glucosidase inhibitors or clinical candidates.

[中图分类号]

R977.1

[基金项目]

国家自然基金青年科学基金资助项目（81302841）；辽宁省高等学校优秀人才支持计划（LJQ2014086）

引用本文 / Get Citation

阎成炟,郭崇真,林建阳.新型α-葡萄糖苷酶抑制剂筛选及药理作用研究进展[J].药物评价研究,2021,44(2):440-445

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收稿日期: 2020-07-16

在线发布日期: 2021-02-03

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