[关键词]
[摘要]
目的 探讨骨松宝颗粒联合硫酸氨基葡萄糖治疗膝骨关节炎的临床疗效。方法 纳入2019年10月—2020年2月于南阳市第二人民医院骨科门诊及住院治疗的86例膝骨关节炎患者作为研究对象,按照随机数表法将患者分为对照组和观察组,每组各43例。对照组患者口服硫酸氨基葡萄糖胶囊,2粒/次,3次/d。观察组在对照组治疗的基础上口服骨松宝颗粒,1袋/次,3次/d。两组各治疗6周。观察两组患者的临床疗效,同时比较两组治疗前后的视觉模拟评分(VAS)、Lysholm评分、血清炎症因子及骨代谢指标水平。结果 治疗后,观察组总有效率为95.34%,显著高于对照组的79.07%,差异具有统计学意义(P<0.05)。治疗后,两组VAS评分显著降低,而Lysholm评分显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,观察组VAS评分显著低于对照组,而Lysholm评分高于对照组,差异均具有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平较显著降低(P<0.05),且治疗后,观察组TNF-α、IL-1β、IL-6水平显著低于对照组,差异均具有统计学意义(P<0.05)。治疗后,两组抗酒石酸盐酸性磷酸酶异构体5b(TRACP-5b)水平显著降低,而骨钙素(BGP)和骨特异性碱性磷酸酶(BALP)水平显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,观察组TRACP-5b水平显著低于对照组,而BGP和BALP水平显著高于对照组,两组比较差异具有统计学意义(P<0.05)。结论 骨松宝颗粒联合硫酸氨基葡萄糖治疗膝骨关节炎的临床疗效较好且安全性高,能明显改善膝关节疼痛症状及关节功能,可能机制与其能显著降低机体炎症因子水平及改善骨代谢有关。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Gusongbao Granules combined with glucosamine sulfate in treatment of knee osteoarthritis. Methods A total of 86 patients with knee osteoarthritis in the department of orthopedics, The Second People's Hospital of Nanyang from October 2019 to February 2020 were included as the research objects. According to the random number table method, the patienthe control group were po administered with Glucosamine Sulfate Capsules, 2 capsules/time, 3 times daily. Patients in observation group were po administered with Gusongbao Granules on the basis of control group, 1 bag per time and 3 times daily. Both groups were treated for a total of 6 weeks. The clinical efficacy in two groups of patients was observed, and the VAS score, Lysholm score, serum inflammatory factors, and bone metabolism indexes of two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 95.34%, which was significantly higher than 79.07% of the control group, and the difference was statistically significant (P<0.05). After treatment, VAS scores of two groups were significantly reduced, while Lysholm scores were significantly increased, with statistically significant differences between two groups before and after treatment (P<0.05). After treatment, VAS score of the observation group was significantly lower than that of the control group, while Lysholm score was higher than that of the control group, with statistically significant differences (P<0.05). After treatment, the levels of TNF-α, IL-1β, and IL-6 in two groups were significantly decreased (P<0.05), and levels of TNF-α, IL-1β, and IL-6 in the observation group were significantly lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, TRACP-5b levels in two groups were significantly decreased, while BGP and BALP levels were significantly increased, with statistically significant differences before and after treatment in the same group (P<0.05). After treatment, TRACP-5b levels in the observation group were significantly lower than those in the control group, while BGP and BALP levels were significantly higher than those in the control group, with statistically significant differences between the two groups (P<0.05). Conclusions Gusongbao Granules combined with glucosamine sulfate in treatment of knee osteoarthritis has good clinical efficacy and high safety, and can significantly improve the symptoms and joint function of the knee joint. The possible mechanism is related to its ability to significantly reduce the expression level of inflammatory factors in the body and improve bone metabolism.
[中图分类号]
R977
[基金项目]