苦参碱具有广泛的生物活性，如保护心、肝、肺、肾、脑、血管作用，对心脏有正性肌力、负性频率、抗心律失常作用，还有升高白细胞，平喘，抗溃疡，抗肝纤维化以及镇静、催眠、镇痛等中枢神经药理作用，也具有抗肿瘤、免疫调节、抗菌、抗病毒、抗炎等药理作用。其中抗肿瘤、心血管保护和治疗病毒性肺炎的药理作用的研究比较深入，希望生产企业开发苦参碱的这些新适应症。苦参碱是一种亲水性的弱碱性药物，易透过生物膜，口服和经皮给药易吸收和分布，约50%原型苦参碱经尿排泄。通过综述苦参碱药动学参数、体内过程，总结苦参碱的药动学研究进展，为合理用药提供参考。推荐将苦参碱试用于病毒性肺炎的治疗。

Matrine has a widespread bioactivities, including protection of heart, liver, lung, kidney, brain and blood vessel, and the effects of positive inotropism, negative chronotropism and antiarrhythmia on heart, and promoting leukocytes, antiasthma, antiulcer, anti-fibrogenesis in liver, and central suppression of sedation, hypnogenesis, analgesia, and antitumor, immunoregulation, antibacteria, anti-virus and anti-inflammation. Amomg them the pharmacologic effects of antitumor, cardiovascular protections, and treatment for viral pulmonitis have be deeply researched, those new indications of matrine are remaining to enterprises to develop. Matrine is a hydrophilic and weakly alkaline drug to easily penetrated through biomembrane. Matrine oral and transdermal administration is easily absorbed and distributed. About 50% prototype matrine is excreted from urine. The pharmacokinetic parameters and process in body of matrine are reviewed, and its research advances on pharmacokinetics is summarized, which provides a reference for rational utilization of matrine. So recommend matrine to try on treatment for viral pulmonitis. We recommend matrine to try on treatment for viral pulmonitis.

R285.5;R945