目的 运用数据挖掘技术研究黄力教授治疗老年高血压的用药规律。方法 收集2013年1月1日-2018年12月31日中日友好医院黄力教授专家门诊处方数据，进行整理和筛选，应用频数分析、关联规则分析及聚类分析方法进行专家处方的挖掘与探索。结果 共收集处方275首，涉及中药197味，累计用药频次4 317次。其中高频药物的药性以平、温、微寒为主，药味以甘、辛、苦为主，归经以肝、脾、心经为主，所属中药功效以平肝熄风、补虚、活血化瘀、安神类为主，所属分类以平抑肝阳、补气、养心安神、活血调经类为主。关联规则分析总结出用药核心配伍组合为"葛根-川芎-龙骨-牡蛎-天麻"。聚类分析显示高频药物可分为4类：重镇安神、活血通络类；平肝补肾类；健脾燥湿化痰类；养心安神、益气活血类。结论 黄力教授治疗老年高血压用药多取甘辛平温之品，注重平肝潜阳、镇惊安神，同时兼顾活血理气、滋补肝肾、养心安神。总结其处方思路为：以核心药对川芎-葛根、龙骨-牡蛎为基础，配天麻钩藤饮合半夏白术天麻汤加减，佐以益气活血、养心安神类药物。

Objective To study the medication rule of Professor Huang Li in treatment of elderly hypertension by using data mining technology. Methods The data of outpatient prescriptions of Huang Li expert in China Japan Friendship Hospital from January 1, 2013 to December 31, 2018,were collected,sorted and screened. Frequency analysis, association rule analysis and cluster analysis were used to mine and explore expert prescriptions. Results A total of 275 prescriptions were collected,involving 197 flavors of traditional Chinese medicine (TCM), with a cumulative frequency of 4 317 times. Among them, the high-frequency drugs are mainly composed of mild, warm and slightly cold properties; the main tastes are sweet, pungent and bitter; the meridians are mainly liver, spleen and heart meridian; the TCM categories are mainly for calming the liver wind, tonifying the deficiency, promoting blood circulation and removing blood stasis, and calming nerves; the classification is mainly for suppressing liver Yang, tonifying Qi, nourishing heart and tranquilizing mind, and promoting blood circulation and regulating menstruation. According to association rule analysis, the core compatibility combination was "Gegen-Chuanxiong-Longgu-Muli-Tianma". Cluster analysis showed that highfrequency drugs could be divided into four categories:calming the nerves, promoting blood circulation and dredging collaterals; smoothing the liver and tonifying the kidney; invigorating the spleen, drying dampness and resolving phlegm;nourishing the heart and tranquilizing the mind, invigorating qi and activating blood circulation. Conclusion Professor Huang Li often uses sweet, pungent, midl and warm drugs in the treatment of elderly hypertension, focusing on calming the liver and suppressing yang, calming the nerves, and promoting blood circulation and regulating Qi, nourishing the liver and kidney, nourishing the heart and tranquilizing the mind. To sum up her prescription ideas:Based on the core drug pair of Gegen-Chuanxiong and Longgu-Muli, combined with Tianma Gouteng Decoction and Banxia Baizhu Tianma Decoction, supplemented with drugs of nourishing the heart and tranquilizing the mind, invigorating Qi and activating blood circulation.

R914.2;R286.2

国家自然科学基金重点项目（81774105）