[关键词]
[摘要]
目的 探讨妇科千金胶囊联合左氧氟沙星治疗慢性宫颈炎的临床疗效。方法 选取2016年5月-2019年5月在延安市人民医院妇产科治疗慢性宫颈炎的患者286例作为研究对象,根据入院单双号分为对照组和观察组,每组各143例。对照组患者口服盐酸左氧氟沙星片,0.5 g/次,1次/d;观察组患者在对照组的基础上口服妇科千金胶囊,0.8 g/次,3次/d。两组均连续治疗4周。观察两组患者的临床疗效和不良反应情况,同时比较两组治疗前后的症状评分、血清学指标。结果 治疗后,观察组治疗总有效率为95.80%,显著高于对照组的79.03%(P<0.05)。治疗后,两组的症状评分均显著降低(P<0.05),且观察组显著低于对照组(P<0.05)。治疗后,两组白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)水平均明显降低(P<0.05),血管内皮生长因子(VEGF)和自然杀伤T细胞(NKTs)水平明显升高,且观察组上述血清学指标均显著优于对照组(P<0.05)。治疗期间,对照组不良反应发生率为15.38%,显著高于观察组的4.20%(P<0.05)。结论 妇科千金胶囊联合左氧氟沙星可有效抑制机体炎性反应,加速症状缓解及宫颈修复,疗效安全显著,对促进慢性宫颈炎病情康复具有积极意义,值得临床推广应用。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Fuke Qianjin Capsules combined with levofloxacin in treatment of chronic cervicitis. Methods A total of 286 patients with chronic cervicitis treated in the department of Obstetrics and Gynecology of Yan'an People's Hospital from May 2016 to May 2019 were selected as the research objects, and were divided into control group and observation group according to the odd and even number of admission, with 143 patients in each group. Patients in the control group were po administered with Levofloxacin Hydrochloride Tablets, 0.5 g/time, and once daily. Patients in the observation group were po administered with Fuke Qianjin Capsules on the basis of the control group, 0.8 g/time, and three times daily. Both groups were treated continuously for 4 weeks. The clinical efficacy and adverse reactions in two groups were observed, and the symptom scores and serological indicators before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 95.80%, which was significantly higher than 79.03% of the control group (P<0.05). After treatment, the symptom scores in two groups were significantly reduced (P<0.05), and the observation group was significantly lower than control group (P<0.05). After treatment, the levels of IL-6, hs-CRP, and TNF-α were significantly decreased in two groups (P<0.05), but the levels of VEGF and NKTs were significantly increased. Moreover, the serological indicators in the observation group were significantly better than those in the control group (P<0.05). During the treatment, the incidence of adverse reactions in the control group was 15.38%, significantly higher than 4.20% in the observation group (P<0.05). Conclusion Fuke Qianjin Capsules combined with levofloxacin can effectively inhibit the body's inflammatory response, accelerate the relief of symptoms and cervical repair, with a safe and significant effect, and has positive significance in promoting the rehabilitation of chronic cervicitis, which is worthy of clinical promotion and application.
[中图分类号]
R984
[基金项目]