目的 探讨滋阴补肾丸联合他达拉非治疗勃起功能障碍的临床疗效。方法 选取2019年4月-2020年4月在日照市妇幼保健院泌尿男科门诊治疗的阴茎勃起功能障碍患者76例作为研究对象，运用随机数字表法将患者随机分为对照组（38例）和观察组（38例）。对照组口服他达拉非片，10 mg/次，在进行性生活前30 min服用，最大服药频率为1次/d。观察组在对照组的基础上加滋阴补肾丸，淡盐水送服，1袋/次，2次/d，连续服用7 d。观察两组患者的临床疗效和不良反应发生情况，同时比较两组治疗前后的性激素水平和国际勃起功能障碍问卷（IIEF-5）评分。结果 治疗后，观察组的总有效率为94.73%，明显高于对照组的84.21%（P<0.05）。治疗后，两组血清总睾酮、卵泡刺激素水平明显升高，雌二醇显著降低（P<0.05）；治疗后，观察组血清总睾酮、卵泡刺激素水平明显高于对照组，雌二醇水平显著低于对照组（P<0.05）。治疗7、14 d后，两组IIEF-5评分均显著升高（P<0.05），且观察组IIEF-5评分显著高于同期对照组（P<0.05）。治疗期间，对照组患者不良反应发生率为26.32%，显著高于观察组的13.16%（P<0.05）。结论 滋阴补肾丸联合他达拉非治疗阴茎勃起功能障碍疗效显著，改善性激素水平，中西药联合治疗优于单用他达拉非，值得临床进一步的推广。

Objective To explore the clinical effect of Ziyin Bushen Pills combined with tadalafil in treatment of erectile dysfunction. Methods Seventy-six patients with erectile dysfunction who were treated in Rizhao Maternal and Child Health Care Hospital from April 2019 to April 2020 were selected as the study subjects, and randomly divided into control group (38 cases) and observation group (38 cases) by random number table method. Patients in the control group were po administered with Tadalafil Tablets, 10 mg/time, take it 30 minutes before sex, and the maximum frequency was once daily. Patients in the observation group were po administered with Ziyin Bushen Pills on the basis of control group on the basis of control group with light saline, 1 bag/time, twice daily for 7 days. The clinical efficacy and adverse reactions of two groups were observed, and the sex hormone levels and international Erectile dysfunction Questionnaire (IIEF-5) scores of two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 94.73%, which was significantly higher than 84.21% of the control group (P<0.05). After treatment, the serum levels of total testosterone and follicle-stimulating hormone were significantly increased, but estradiol was significantly decreased in two groups (P<0.05). After treatment, the serum levels of total testosterone and follicle-stimulating hormone in the observation group were significantly higher than those in the control group, and the levels of estradiol were significantly lower than those in the control group (P<0.05). After 7 and 14 days of treatment, IIEF-5 score in two groups was significantly increased (P<0.05), and IIEF-5 score in the observation group was significantly higher than that in the control group at same period (P<0.05). During the treatment, the incidence of adverse reactions in the control group was 26.32%, which was significantly higher than 13.16% in the observation group (P<0.05). Conclusion Ziyin Bushen Pills combined with tadalafil has a significant effect on erectile dysfunction, and improves the sex hormone level, and the effect is superior to the single use of tadalafil, which is worthy of further clinical promotion.

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