女贞子药对及女贞子的活性成分红景天苷、齐墩果酸和熊果酸均有平喘作用。红景天苷、齐墩果酸和熊果酸有抗脂多糖、脓毒症、休克、百草枯、氯气、油酸和缺氧引起的急性肺损伤作用，也有抗缺氧、香烟烟雾、二氧化硅、博来霉素和野百合碱引起的慢性肺损伤和肺纤维化作用。它们的肺保护作用的共同机制可能是：（1）上调T-bet基因表达和下调GATA3基因表达，调节Th1/Th2之间的平衡，抑制IgE生成和炎性细胞因子表达，减轻肺和气道的炎症反应；（2）上调Nrf-2通路，发挥抗氧化作用，减轻肺组织的氧化应激反应引起的炎性肺损伤；（3）激活PI3K/AKT信号通路和阻滞TLR4/MyD88/NF-κB炎性信号通路，保护肺上皮细胞；（4）阻滞TGF-β1/Smad通路，抑制胶原合成和成纤维细胞增生，减轻肺纤维化形成。女贞子药对和红景天苷有抗病毒性肺炎作用，齐墩果酸和熊果酸具有广谱抗病毒作用，除了直接抗病毒作用外，提高机体的免疫功能也是作用机制之一。

Fructus Ligustri Lucidi pair and the active components of Fructus Ligustri Lucidi(salidroside, oleanolic and usrolic acids) have antiasthmatic effects. Salidroside, oleanolic and usrolic acids have the antagonisms on acute lung injuries induced by lipopolysaccharide, sepsis, shock, paraquat, chlorine, oleic acid and hypoxia, and the antagonisms on chronic lung injuries and pulmonary fibrosis induced by hypoxia, cigarette smoke, SiO2, bleomycin, monocrotaline. The common mechanisms of lung protection may be:(1) up-regulating the expression of Tebt mRNA, and down-regulating the expression of GATA3 mRNA, to regulate the Th1/Th2 balance, to inhibt the the expression of IgE and inflammatory cytokines, so can alleviate inflammation of lung and airway; (2) up-regulating Nrf-2 pathway to show antioxidation, so can alleviate oxidation stress-induced lung inflammatory injury; (3) activating PI3K/AKT pathway and blocking TLR4/MyD88/NF-κB pathway to protect pulmonary epithelial cells; (4) blocking TGFβ1/Smad pathway to inhibit collagen synthesis and fibrocyte hyperplasia, so can alleviate pulmonary fibrogenesis. Fructus Ligustri Lucidi pair and salidroside have the effects against virus pneumonia. Oleanolic and usrolic acids have broad-spectrum antiviral effects. The mechanisms are direct effect against virus, and promote organism immunopotency against virus.

R285.5;R964