5-羟甲基糠醛（5-HMF）是中药中广泛存在的化学成分，在中药炮制、贮藏、配伍过程中含量变化明显。现代药理学研究表明5-HMF具有抗氧化、改善学习记忆、抗过敏、保护神经细胞、抗炎等药理作用。结合国内外有关文献，对5-HMF在中药道地性、炮制加工、贮藏方面的含量变化及药理作用进行综述，以期为提升中药材质量标准和临床合理用药提供参考。

5-Hydroxymethyl furfural (5-HMF) is a relatively wide range of chemical constituents in traditional Chinese medicine. Its content changes significantly during the processing, storage, and compatibility of traditional Chinese medicine. Modern pharmacological studies have shown that 5-HMF has anti-oxidation, improve learning and memory, anti-allergy, protect nerve cells, anti-infla matory and other pharmacological effects. This article summarizes the content changes and pharmacological effects of 5-HMF in the authenticity, processing andstorage of traditional Chinese medicine in combination with relevant literatureathome and abroad, in order to provide a reference for improving the quality standards of traditional Chinese medicine and clinical rational use of medicine.

R283.1;R285.5

山西省中医药中老年健康产业技术创新联盟项目（JKCY201904）；2020年度山西省研究生教育创新项目（2020SY460）；山西省中医药研究院院级课题（201905）；山西中医药大学学科建设项目（1008Z4）；2020年山西中医药大学校级研究生创新项目（2020CX039）