[关键词]
[摘要]
目的 系统的评价外用他克莫司(软膏或漱口水)治疗糜烂型口腔扁平苔藓的有效性和安全性。方法 计算机检索PubMed、EMbase、Cochrane Library、OVID、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文期刊全文数据库(VIP)和万方数据库,检索年限均为数据库建库至2019年12月,搜索他克莫司(软膏或漱口水)与皮质类固醇药物(对照药)比较治疗糜烂型口腔扁平苔藓的临床随机对照试验(RCTs),采用Stata1 4.2软件进行Meta-分析。结果 共纳入23个RCTs、共1 269例患者。Meta-分析结果显示:与对照组比较治疗组有效率(RR=1.11,95% CI=1.02~1.22,P=0.022)及安全性(RR=0.62,95% CI=0.44~0.88,P=0.007)均有统计学差异(P<0.05),其中0.03%他克莫司比0.1%他克莫司更安全。结论 治疗糜烂型口腔扁平苔藓,他克莫司较皮质类固醇药物的安全性更好,不良反应更低。
[Key word]
[Abstract]
Objective To systematically evaluate the efficacy and safety of topical tacrolimus (ointment or mouthwash) in the treatment of erosive oral lichen planus. Methods The databases PubMed, EMbase, the Cochrane Library, OVID, CNKI, CBM, VIP and Wanfang Data were searched for controlled trials (RCTs) of tacrolimus (ointment or mouthwash) compared with corticosteroid drug (placebo) in the treatment of erosive oral lichen planus, from database building to December 2019. Meta-analysis was performed using Stata1 4.2 software. Results A total of 23 RCTs with 1 269 patients were included. Meta-analysis results showed that compared with the control group, the effective rate (RR=1.11, 95% CI=1.02-1.22, P=0.022) and safety (RR=0.62, 95% CI=0.44-0.88, P=0.007) of the treatment group were statistically significant differences (P<0.05), and the 0.03% concentration was safer than the 0.1% concentration. Conclusion Tacrolimus is safer and has fewer adverse reactions than corticosteroid in the treatment of erosive oral lichen planus.
[中图分类号]
R988.2
[基金项目]
国家癌症中心攀登基金项目(NCC201803B006);河北省科技厅重点研发项目(18277730D);河北省卫生厅科研基金项目(20170691)