目的 研究拉贝洛尔联合尼莫地平对妊娠高血压患者血液流变学和氧化应激的影响。方法 选择2013年1月—2017年12月长安医院收治的80例妊娠高血压患者作为研究对象，将患者随机分为对照组和观察组，每组各40例。对照组患者口服尼莫地平片，20 mg/次，1次/d。观察组在对照组的基础上口服盐酸拉贝洛尔片，1片/次，3次/d。两组均持续治疗10 d。观察两组患者的临床疗效和妊娠结局，同时比较两组治疗前后的血液流变学和氧化应激情况。结果 治疗后，观察组的总有效率为90.00%，显著高于对照组的77.50%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，观察组的各不良妊娠发生率均显著低于对照组（P<0.05），自然分娩率显著高于对照组（P<0.05）。两组治疗后的丙二醛（MDA）和超氧化物歧化酶（SOD）水平均改善（P<0.05），且观察组MDA和SOD水平显著优于对照组（P<0.05）。治疗后，两组血小板聚集率和血液黏稠度均显著降低（P<0.05）；治疗后，观察组血小板聚集率和血液黏稠度显著低于对照组（P<0.05）。结论 拉贝洛尔联合尼莫地平可以改善妊娠高血压患者的妊娠情况，提高治疗有效率，改善血液流变学和氧化应激水平。

Objective To study the effect of labetalol combined with nimodipine on hemorheology and oxidative stress in pregnant hypertensive patients. Methods A total of 80 patients with gestational hypertension admitted to Chang'an Hospital from January 2013 to December 2017 were selected as the study subjects, and randomly divided into control group and an observation group, with 40 patients in each group. Patiens in the control group were po administered with Nimodipine Tablets, 20 mg/time and once daily. Patiens in the observation group were po administered with Labetalol Hydrochloride Tablets on the basis of control group, 1 tablet/time, three times daily. Both groups were treated continuously for 10 d. The clinical efficacy and pregnancy status in two groups were observed, and the hemorheology and oxidative stress in two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 90.00%, which was significantly higher than 77.50% of the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the incidence of adverse pregnancy in the observation group was significantly lower than that in the control group (P<0.05), and the rate of natural delivery was significantly higher than that in the control group (P<0.05). After treatment, MDA and SOD levels in two groups were improved (P<0.05), and MDA and SOD levels in the observation group were significantly better than those in the control group (P<0.05). After treatment, the platelet aggregation rate and blood viscosity were decreased significantly in two groups (P<0.05). After treatment, the platelet aggregation rate and blood viscosity in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Labetalol combined with nimodipine can improve the pregnancy status of pregnant hypertensive patients, improve the effective rate of treatment, and improve the level of hemorheology and oxidative stress.

R984;R972