目的 探讨丹参注射液联合硫酸镁治疗胎儿生长受限的临床疗效。方法 选取2016年5月—2019年6月宝鸡市妇幼保健院84例胎儿生长受限孕妇为研究对象，根据就诊单双号将患者分为对照组（42例）和观察组（42例）。对照组患者静脉滴注丹参注射液联合低分子右旋糖酐氨基酸注射液治疗，将20 mL丹参注射液加入到10%葡萄糖溶液500 mL中静脉滴注，30~40滴/min，1次/d；低分子右旋糖酐氨基酸注射液500 mL/d静脉滴注。观察组患者静脉滴注丹参注射液联合硫酸镁注射液治疗，将30 mL硫酸镁注射液加入到5%葡萄糖溶液500 mL中静脉滴注，1~2 g/h，1次/d；丹参注射液用法同对照组，两组均持续用药1周，之后间隔3~5 d再持续用药1周，总用药周期为3周。观察两组患儿的临床疗效、胎儿生长及新生儿发育情况，同时比较两组治疗前后的血液流变学指标。结果 治疗后，观察组患者总有效率为92.86%，显著高于对照组的76.19%，两组总有效率比较存在统计学差异（P<0.05）。治疗后，观察组胎儿头围、腹围、股骨长度、双顶径的增长值均显著高于对照组（P<0.05）。治疗后两组全血低切黏度、血浆黏度及红细胞压积均显著降低（P<0.05）；且观察组各血流变指标水平均显著低于对照组（P<0.05）。治疗后，两组患者D-二聚体（D-D）、纤维蛋白原（FIB）水平均显著降低，凝血酶原时间（PT）和活化部分凝血酶原时间（APTT）均显著升高（P<0.05），且观察组各凝血功能指标均明显优于对照组（P<0.05）。观察组新生儿娩出胎龄、出生体质量、身长及1 min Apgar评分均显著优于对照组（P<0.05）。结论 丹参注射液联合硫酸镁可有效改善患者血流变指标指标，促进胎儿生长发育，疗效显著，值得临床进行应用推广。

Objective To investigate the clinical effect of Danshen Injection combined with magnesium sulfate in treatment of fetal growth restriction. Methods A total of 84 pregnant women with fetal growth restriction from May 2016 to June 2019 in Baoji Maternal and Child Health Care Hospital were selected as the study subjects, and the patients were divided into control group (42 cases) and observation group (42 cases) according to the odd-even number of visits. Patients in the control group were treated with intravenous drip of Danshen Injection combined with Dextran 40 and Amino Acid Injection, 20 mL Danshen injection was added to 500 mL 10% glucose solution for 30-40 drops/min, once daily, and Dextran 40 and Amino Acid Injection was 500 mL/d. Patients in the observation group were treated with intravenous infusion of Danshen Injection combined with Magnesium Sulfate Injection. 30 mL of Magnesium Sulfate Injection was added to 500 mL 5% glucose solution for intravenous infusion, 1-2 g/h, once daily. The usage of Danshen Injection was the same as that of the control group. Both groups were given continuous medication for one week, and the interval between 3-5 d was given continuous medication for one week, with a total medication cycle of three weeks. After treatment, the clinical efficacy, fetal growth and neonatal development in two groups were observed, and the hemorheology indexes before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 92.86%, which was significantly higher than 76.19% of the control group, and the total effective rate between two groups was statistically different (P<0.05). After treatment, The growth values of fetal head circumference, abdominal circumference, femoral length, double parietal diameter in the observation group were significantly higher than those in the control group (P<0.05). After treatment, the whole blood viscosity, plasma viscosity, and hematocrit were significantly decreased in two groups (P<0.05), and the levels of hemorheology indexes in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of D-D and FIB in two groups were significantly decreased, PT and APTT were significantly increased (P<0.05), and the coagulation function indexes in the observation group were significantly better than those in the control group (P<0.05). Neonatal delivery age, birth weight, body length and 1 min Apgar score of newborn in the observation group were significantly better than the control group (P<0.05). Conclusion Danshen Injection combined with magnesium sulfate can effectively improve hemorheology indexes of patients and promote fetal growth and development, with significant curative effect, which is worthy of clinical application and promotion.

R984

中华国际科学交流基金会检验检测科技专项基金（Z2018LSXB007）