目的 建立电感耦合等离子体光谱法（ICP-OES）测定特灵眼药中铁（Fe）、铅（Pb）、钙（Ca）、铝（Al）、镁（Mg）、硼（B）、钠（Na）含量。方法 采用微波消解法对样品进行前处理，电感耦合等离子体发射光谱法测定特灵眼药中Fe、Pb、Ca、Al、Mg、B、Na含量。结果 Fe、Pb、Ca、Al、Mg、B、Na线性范围为0.1~50.0 μg/mL（r=0.993 0~0.999 9）；检测限为0.591 2~45.867 9 mg/kg；重复性试验的RSD均小于6%；加样回收率为101.1%~110.0%，RSD为4.4%~5.7%，均小于6%。结论 该方法操作简便、准确，重复性好，可用于特灵眼药中铁、铅、钙等7种金属元素含量的同时测定。

Objective An ICP-OES method was established for the determination of Fe、Pb、Ca、Al、Mg、B、Na in Teling Ophthalmic Remedy. Methods The sample was pretreated by microwave digestion method, and the contents of Fe, Pb, Ca, Al, Mg, B, Na in Teling Ophthalmic Remedy were determined by ICP-OES method. Results The linear range of Fe, Pb, Ca, Al, Mg, B, Na concentration was 0.1-50.0 μg/mL(r=0.993 0-0.999 9), the detection limit was 0.591 2-45.867 9 mg/kg, the RSD of the repeated tests was less than 6%. The recoveries were 101.1%-110.0%, and RSD was 4.4%-5.7%, was less than 6%. Conclusions The method is simple, accurate and reproducible. It can be used for simultaneous determination of Fe, Pb, Ca, and other 7 metal elements in Teling Ophthalmic Remedy.

R988.1;R927.2

河北省科技计划项目（17272504D）