[关键词]
[摘要]
目的 研究复方谷氨酰胺联合柳氮磺吡啶治疗溃疡性结肠炎的临床疗效。方法 选择2017年1月-2019年1月榆林市星元医院的120例溃疡性结肠炎患者作为研究对象,采用抽签法随机分为对照组和观察组,每组各60例。对照组患者口服柳氮磺吡啶肠溶片,6片/次,3次/d。观察组患者在对照组的基础上口服复方谷氨酰胺肠溶胶囊,3粒/次,3次/d。两组均治疗4周。观察两组患者的临床疗效,比较两组治疗前后的相关症状、评分情况,以及炎性因子水平。结果 治疗后,观察组的总有效率为91.67%,明显高于对照组的71.67%(P<0.05)。治疗后,观察组的黏液脓血便消失时间为(10.13±1.27)d,明显短于对照组的(19.73±2.45)d(P<0.05)。两组治疗后的疾病活动指数和腹痛程度评分均明显降低(P<0.05),且观察组明显更低(P<0.05)。两组治疗后的血清白细胞介素(IL)-6、肿瘤坏死因子-α(TNF-α)、IL-8、超敏C反应蛋白(hs-CRP)水平均明显降低(P<0.05),且观察组明显更低(P<0.05)。结论 复方谷氨酰胺联合柳氮磺吡啶对溃疡性结肠炎的疗效较佳,能明显减轻腹痛程度,改善炎症因子水平,降低疾病活动指数。
[Key word]
[Abstract]
Objective To study the clinical efficacy of compound glutamine combined with sulfasalazine in treatment of ulcerative colitis. Methods A total of 120 patients with ulcerative colitis in the Xing Yuan Hospital of Yulin from January 2017 to January 2019 were selected as the research objects, and randomly divided into control group and observation group by lottery, with 60 patients in each group. Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 6 tablets/time, three times daily. Patients in the observation group were po administered with Compound Glutamine Entersoluble Capsules on the basis of the control group, 3 grains/time, three times daily. Both groups were treated for 4 weeks. After treatment, the clinical efficacy in two groups was observed, and the related symptoms, scores, and inflammatory factor levels in two groups before and after treatment were compared. Results After treatment, the effective rate of the observation group was 91.67%, which was significantly higher than 71.67% of the control group (P<0.05). After treatment, the disappearance time of mucous pus blood in the observation group was (10.13 ±1.27) d, which was significantly shorter than (19.73 ±2.45) d in the control group (P<0.05). After treatment, disease activity index and abdominal pain degree score were significantly reduced in two groups (P<0.05), and were significantly lower in the observation group (P<0.05). After treatment, the serum levels of IL-6, TNF-α, IL-8, and hs-CRP in two groups were significantly decreased (P<0.05), and those indexes in the observation group were significantly lower (P<0.05). Conclusion Compound glutamine combined with sulfasalazine has a better effect on ulcerative colitis, can significantly reduce the degree of abdominal pain, improve the level of inflammatory factors, reduce the disease activity index.
[中图分类号]
R975
[基金项目]