目的 探讨宫颈癌患者中HNF1A-AS1、HNF1A的表达及其临床意义。方法 选取2013年-2018年延安市人民医院收集的187例宫颈癌患者的癌组织及对应的癌旁正常组织标本，通过实时荧光定量PCR检测宫颈癌患者肿瘤组织中HNF1A-AS1、HNF1A的表达情况，探讨HNF1A-AS1、HNF1A表达水平与宫颈癌患者临床特征和生存期之间的关系。结果 HNF1A-AS1在宫颈癌组织中高表达（P=0.022）；HNF1A-AS1高表达与宫颈癌患者肿瘤分期（P<0.001）、是否原位癌（P=0.013）、是否淋巴结转移（P=0.002）、是否远端转移（P<0.001）以及HPV型别相关（P=0.006）；HNF1A-AS1高表达组总体生存率明显低于HNF1A-AS1低表达组（χ²=10.33，P=0.002）。HNF1A在宫颈癌组织中高表达（P=0.044），且HNF1A的相对表达量与HNF1A-AS1表达呈正相关（P<0.001）；HNF1A高表达与宫颈癌患者肿瘤分期（P=0.002）、是否原位癌（P=0.007）、是否淋巴结转移（P=0.005）、是否远端转移（P<0.001）以及HPV型别相关（P=0.003）；HNF1A高表达组总体生存率明显低于HNF1A低表达组（χ²=6.10，P=0.013）。结论 HNF1A-AS1、HNF1A促进宫颈癌发生和发展，并与宫颈癌患者生存期相关。

Objective To investigate the expression and clinical significance of HNF1A-AS1 and HNF1A in patients with cervical cancer.Methods The cancer tissues and corresponding normal adjacent tissues of 187 cervical cancer patients collected in Yan'an People's Hospital from 2013 to 2018 were selected, and the expression levels of HNF1A-AS1 and HNF1A in the tumor tissues of cervical cancer patients were detected by real-time fluorescence quantitative PCR, so as to explore the relationship between the expression of HNF1A-AS1 and HNF1A, and the clinical characteristics, survival time of cervical cancer patients. Results HNF1AAS1 was highly expressed in cervical cancer tissues (P=0.022). High HNF1A-AS1 expression was associated with tumor stage (P<0.001), carcinoma in situ (P=0.013), lymph node metastasis (P=0.002), distal metastasis (P<0.001), and HPV type (P=0.006) in patients with cervical cancer. The overall survival rate of the HNF1A-AS1 high expression group was significantly lower than that of the HNF1A-AS1 low expression group (χ²=10.33, P=0.002). HNF1A was highly expressed in cervical cancer tissues (P=0.044), and the relative expression of HNF1A was positively correlated with the expression of HNF1A-AS1 (P<0.001). High expression of HNF1A was associated with tumor stage (P<0.002), carcinoma in situ (P=0.007), lymph node metastasis (P=0.005), distal metastasis (P<0.001), and HPV type (P=0.003) in patients with cervical cancer. The overall survival rate of the HNF1A-AS1 high expression group was significantly lower than that of the low expression group (χ²=6.10, P=0.013). Conclusion HNF1A-AS1 and HNF1A promote the occurrence and development of cervical cancer, and are related to the survival of cervical cancer patients.

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