[关键词]
[摘要]
目的 探讨小儿消积止咳颗粒治疗小儿急性支气管炎伴积食的临床疗效。方法 选取2016年5月-2020年1月江苏大学附属武进医院收治的98例急性支气管炎伴积食患儿作为研究对象。采用随机数字表分组法分为对照组(46例)与观察组(52例)。对照组给予西医常规干预。观察组在对照组治疗基础上口服小儿消积止咳颗粒,其中年龄小于1岁者,3 g/次;1~3岁者,6 g/次;3~5岁者,9 g/次;大于5岁者,12 g/次;3次/d。两组均维持治疗7 d。观察两组中医疗效及疾病临床疗效,对比治疗前后两组患儿的中医症状(主症、次症、舌脉)积分、血气分析指标[氧分压(pO2)、二氧化碳分压(pCO2)、血氧饱和度(SaO2)]变化情况,另观察治疗期间患儿不良反应发生情况。结果 治疗后,观察组中医疗效总有效率为98.08%,显著高于对照组的84.78%,差异有统计学意义(P<0.05)。治疗后,观察组疾病临床疗效总有效率为94.23%,显著高于对照组的80.43%,差异有统计学意义(P<0.05)。治疗后,两组主症、次症、舌脉及症状总积分均较治疗前降低(P<0.05);且观察组治疗后主症、次症、舌脉及症状总积分均较对照组降低(P<0.05)。两组治疗后pO2、SaO2均显著升高,pCO2显著降低,差异均有统计学意义(P<0.05);且观察组治疗后pO2、SaO2显著高于对照组,pCO2均低于对照组,差异均有统计学意义(P<0.05)。治疗期间,两组不良反应发生率比较差异无统计学意义。结论 小儿消积止咳颗粒治疗小儿急性支气管炎伴积食,可明显促进症状减轻,改善血气分析指标,提升临床疗效,且安全性良好。
[Key word]
[Abstract]
Objective To explore the clinical effect of Xiaoji Zhike Granules in treatment of acute bronchitis with food accumulation in children. Methods A total of 98 children with acute bronchitis and accumulated food admitted to Wujin Hospital Affiliated to Jiangsu University from May 2016 to January 2020 were selected as the research objects. Patients were divided into control group (46 cases) and observation group (52 cases) by random number table grouping method. Patients in the control group was given routine western medicine intervention. Patients in the observation group were po administered with Xiaoji Zhike Granules, age <1 year old, 3 g/time, age ≥ 1 year old and ≤ 3 years old were 6 g/time; age over 3 years old and ≤ 5 years were 9 g/time; over 5 years old, 12 g/time; three times daily. Both groups were treated for 7 days. After treatment, the curative effect of traditonal Chinese medicine, and clinical curative effect of diseases in two groups were observed, and the changes of TCM symptoms (main symptom, secondary symptom, tongue vein) score, blood gas analysis indexes pO2, pCO2, SaO2 in two groups before and after treatment were compared, and the occurrence of adverse reactions in the children during treatment were observed. Results After treatment, the total effective rate of TCM in the observation group was 98.08%, which was significantly higher than 84.78% in the control group, and the difference was statistically significant (P<0.05). After treatment, the total effective rate of clinical efficacy was 94.23% in the observation group, which was significantly higher than 80.43% in the control group, with statistically significant difference (P<0.05). After treatment, the scores of main symptoms, secondary symptoms, tongue vein and total symptoms in two groups were lower than before treatment (P<0.05). After treatment, the scores of the main symptoms, secondary symptoms, tongue vein and total symptoms in the observation group were lower than those in the control group (P<0.05). After treatment, pO2 and SaO2 were significantly increased, but pCO2 was significantly decreased in two groups, with statistically significant differences (P<0.05). After treatment, pO2 and SaO2 in the observation group were significantly higher than those in the control group, and pCO2 was lower than that in the control group, with statistically significant differences (P<0.05). During treatment, there was no statistically significant difference in the incidence of adverse reactions between two groups. Conclusion Xiaoji Zhike Granules in treatment of acute bronchitis with food accumulation in children can significantly promote the reduction of symptoms, improve blood gas analysis indicators, enhance clinical efficacy, with good safety.
[中图分类号]
R974;R975
[基金项目]
国家重点研发计划项目[中药口服制剂先进制造关键技术与示范研究(2019YFC1712000)]