[关键词]
[摘要]
氧化苦参碱具有广泛的生物活性,如保护心、肝、肺、肾、脑、血管作用,对心脏有正性肌力、负性频率、抗心律失常作用,还有升高白细胞,平喘,抗溃疡,抗纤维化以及镇静、催眠、镇痛等中枢神经药理作用,也具有抗肿瘤、免疫调节、抗菌、抗病毒、抗炎等药理作用。氧化苦参碱是一种亲水性很强的弱碱性药物,易被代谢成苦参碱,尤其在口服给药时可被看做为苦参碱的前药。通过综述氧化苦参碱药动学参数、体内过程,总结氧化苦参碱的药动学研究进展,为合理用药提供参考。
[Key word]
[Abstract]
Oxymatrine has a widespread bioactivities, including protection of heart, liver, lung, kidney, brain and blood vessel, and the effects of positive inotropism, negative chronotropism and antiarrhythmia on heart, and promoting leukocytes, antiasthma, antiulcer, anti-fibrogenesis, and central suppression of sedation, hypnogenesis, analgesia, and antitumor, immunoregulation, antibacteria, anti-virus and anti-inflammation. Oxymatrine is a strong hydrophilic and weakly alkaline drug. Oxymatrine is easily transformed into matrine, especially when it is given orally. Oxymatrine can be regarded as a prodrug of matrine. The pharmacokinetic parameters and process in body of oxymatrine are reviewed, and its research advances on pharmacokinetics is summarized, which provides a reference for rational utilization of oxymatrine.
[中图分类号]
R285.5;R969.1
[基金项目]