结直肠癌是世界上第3大常见癌症，化疗贯穿整个治疗过程，但其耐药的发生成为癌症死亡和复发的主要原因，亟需寻找辅助化疗药治疗的药物增加其疗效。姜黄素是美国国立肿瘤学会所承认的广谱抗癌药物，其作用机制是通过调控相关蛋白表达、上皮间充质转化分子标志物、结直肠癌干细胞识别标志物、相关信号通路、自噬和相关因子。综述姜黄素逆转逆转结直肠癌化疗耐药的机制，旨在为科研探索和临床治疗、预防提供更好的研究思路和应用价值。

Colorectal cancer is the third most common cancer in the world. Chemotherapy runs through the whole process of cancer treatment, but its drug resistance has become the main cause of cancer death and recurrence. Therefore, there is an urgent need to find adjuvant chemotherapeutic drugs to increase its efficacy. Curcumin is a broad-spectrum anticancer drug recognized by the American National Society of Oncology. its mechanism is through the regulation of related protein expression, epithelial mesenchymal transformation molecular markers, colorectal cancer stem cell recognition markers, related signal pathways, autophagy and related factors. Therefore, the mechanism of reversing chemotherapy resistance is reviewed in order to provide better research ideas and application value for scientific research, clinical treatment and prevention.

R285.5;R979.1

国家自然基金面上项目（81973728）；天津市自然科学基金资助项目（18JCZDJC36600）