目的 探讨银杏内酯注射液对缺血性血管性认知障碍患者认知功能及血清血清超氧化物歧化酶（SOD）、谷胱甘肽（GSH）的影响。方法 选择2018年1月—2019年1月沈阳医学院附属中心医院治疗的缺血性血管性认知障碍患者40例作为研究对象，采用随机数字法将患者随机分为对照组和观察组，每组各20例。对照组患者进行常规治疗。观察组在常规治疗基础上静脉滴注银杏内酯注射液，10 mL加入0.9%生理盐水250 mL稀释，1次/d。两组患者均连续治疗14 d。观察两组患者治疗前后的简易智力状态检查量表（MMSE）评分、日常生活活动能力量表（ADL）和血清抗氧化指标水平。结果 治疗后，两组患者认知能力明显改善，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，观察组患者认知能力的改善显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者生活能力明显改善，同组治疗前后比较差异具有统计学意义（P<0.05）；观察组患者生活能力的改善显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，观察组血清SOD、GSH水平显著升高，同组比较差异具有意义（P<0.05）；治疗后，与对照组比较，观察组患者血清SOD、GSH水平均显著升高，两组比较差异具有统计学意义（P<0.05）。结论 缺血性血管性认知障碍患者在常规治疗的基础上加用银杏内酯注射液体不仅可以在短期内改善智能状态，而且可以显著提高日常生活能力，其机制可能是与银杏内酯的抗氧化应激作用带来的神经损伤修复作用有关。

Objective To investigate the effects of Ginkgolide Injection on cognitive function and serum SOD and GSH in patients with ischemic vascular cognitive impairment. Methods Patients (40 ceses) with ischemic vascular cognitive impairment in the Central Hospital Affiliated to Shenyang Medical College from January 2018 to January 2019 were devided into control and observation group by random number method, and each group had 20 ceses. Patients in the control group were received routine treatment. Patients in the observation group were iv administered with Ginkgolide Injection on the basis of control group, 10 mL was diluted with 0.9% normal saline 250 mL, once daily. Both groups were treated continuously for 14 d. The cognitive function, living ability, and serum antioxidant levels in two groups were observed before and after treatment. Results After treatment, the cognitive ability of patients in two groups was significantly improved, and the difference before and after treatment in the same group was statistically significant (P<0.05). After treatment, the improvement of cognitive ability in the observation group was significantly better than that in the control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the living ability in two groups was significantly improved, and the difference before and after treatment in the same group was statistically significant (P<0.05). And the improvement of living ability in the observation group was significantly better than that in the control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the serum levels of SOD and GSH in the observation group were significantly increased, the differences before and after treatment in the same group were statistically significant (P<0.05). After treatment, compared with the control group, the serum SOD and GSH levels in the observation group were significantly increased, and the differences between two groups were statistically significant (P<0.05). Conclusion Patients with ischemic vascular cognitive impairment adding Ginkgolide Injection on the basis of conventional treatment can not only improve the state of intelligence in a short time, but also significantly improve the ability of daily living, the mechanism may be related to the effect of antioxidant stress of ginkgolide on nerve damage repair.

R971

沈阳医学院青年科学研究基金（20192041）