目的 探讨双歧杆菌四联活菌片联合多潘立酮对小儿功能性消化不良胃电节律、血浆P物质及胃动素水平的影响。方法 选取2016年3月—2019年3月徐州市第一人民医院108例功能性消化不良患儿作为研究对象，根据随机数字表法将患者分为对照组和观察组，每组各54例。对照组患儿餐前30 min口服多潘立酮混悬液，3岁以内3~4 mL/次，3次/d；4~6岁患儿5~6 mL/次，3次/d；7岁以上患儿7~10 mL/次，3次/d。观察组患儿在对照组的基础上口服双歧杆菌四联活菌片，1~6岁患儿1.0 g/次，2~3次/d；6岁以上患儿1.0~1.5 g/次，3次/d。两组均连续治疗14 d。观察两组患儿的临床疗效，同时比较两组治疗前后的症状评分、胃电节律异常发生率、血浆P物质和胃动素水平。结果 治疗后，观察组患儿治疗总有效率为94.44%，显著高于对照组的79.63%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者各症状评分均明显降低（P<0.05），且观察组症状评分显著低于对照组（P<0.05）。治疗后，两组患儿餐前及餐后胃电节律异常发生率均明显降低（P<0.05），且观察组胃电节律异常发生率显著低于对照组（P<0.05）。治疗后，两组患儿血浆P物质及胃动素水平均明显升高（P<0.05），且观察组P物质及胃动素水平显著高于对照组（P<0.05）。结论 双歧杆菌四联活菌片联合多潘立酮可通过改善胃电节律、提高血浆P物质及胃动素水平的影响来改善患儿临床症状，疗效确切，值得在小儿功能性消化不良治疗中应用推广。

Objective To investigate the effects of Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus combined with domperidone on gastric electric rhythm, plasma substance P, and motilin levels in children with functional dyspepsia. Methods A total of 108 children with functional dyspepsia in Xuzhou NO.1 People's Hospital from March 2016 to March 2019 were selected as the research objects. According to the random number table method, the patients were divided into the control group and the observation group, with 54 patients in each group. Children in the control group were po administered with Domperidone Suspension at 30 min before meal, 3-4 mL/time, and three times daily for children within 3 years old. 5-6 mL/time, three times daily for children aged 4-6 years, and 7-10 mL/time, three times daily for children over 7 years old. Children in the observation group were po administered with Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus on the basis of control group, children aged 1-6 years were given 1.0 g/time, 2-3 times/daily. Children over 6 years of age, 1.0-1.5 g/time, three times daily. Both groups received continuous treatment for 14 days. After treatment, the clinical efficacy in two groups of children was observed, and the symptom scores, incidence of abnormal gastric electric rhythm, plasma substance P, and motilin levels of two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 94.44%, which was significantly higher than 79.63% of the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the symptom scores in two groups were significantly decreased (P<0.05), and the symptom scores of the observation group were significantly lower than those of the control group (P<0.05). After treatment, the incidence of abnormal gastric electric rhythm in two groups was significantly decreased (P<0.05), and the incidence of abnormal gastric electric rhythm in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the plasma levels of substance P and motilin in two groups were significantly increased (P<0.05), and the levels of substance P and motilin in the observation group were significantly higher than those in the control group (P<0.05). Conclusion Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus combined with domperidone can improve the clinical symptoms of children by improving gastric electric rhythm and increasing the influence of substance P in plasma and motilin level. It has a definite effect and is worthy of application and promotion in treatment of functional dyspepsia in children.

R975

国家自然科学基金青年项目（81602101）