目的 观察注射用丹参多酚酸联合阿司匹林和阿托伐他汀治疗大面积脑梗死的神经功能改善情况及梗死体积的变化。方法 选取2016年4月-2019年9月驻马店市中心医院收治的大面积脑梗死患者108例为研究对象。随机将患者分为对照组（50例）和观察组（58例）。对照组给予阿司匹林肠溶片，100 mg/d；阿托伐他汀钙片，40 mg/d。观察组在对照组治疗的基础上静脉滴注注射用丹参多酚酸，0.13 g/d。两组患者均输液治疗2周。观察并比较两组患者的美国国立卫生院卒中量表（NIHSS）评分、Barthel指数评分及脑梗死体积。结果 治疗后1个月及3个月时，对照组NIHSS评分显著降低；治疗后2周、1个月及3个月，观察组NIHSS评分显著降低，同组治疗前后比较差异具有统计学意义（P<0.01）。治疗后2周、1个月及3个月，观察组NIHSS评分显著低于同期对照组（P<0.01）。治疗1个月及3个月时，两组Barthel评分均显著升高，同组治疗前后比较差异具有统计学意义（P<0.01）；且观察组Barthel评分显著高于同期对照组（P<0.01）。对照组在治疗3个月时脑梗死体积较治疗前显著降低，观察组在治疗1个月及3月时脑梗死体积显著降低，同组治疗前后比较差异具有统计学意义（P<0.01）。治疗1个月时，观察组脑梗死体积显著低于对照组，两组间比较差异有统计学意义（P<0.01）。结论 注射用丹参多酚酸联合阿司匹林和阿托伐他汀治疗大面积脑梗死患者可降低患者病死率，对患者生活质量、神经功能恢复及梗死体积均有一定的影响。

Objective To observe the improvement of nerve function and the change of infarct volume in treatment of massive cerebral infarction with Salvianolic Acid for Injection. Methods A total of 108 patients with massive cerebral infarction admitted to Zhumadian Central Hospital from April 2016 to September 2019 were selected as the research objects. Patients were randomly divided into control group (50 cases) and observation group (58 cases). Patients in the control group were given Aspirin Entericcoated Tablets at 100 mg/d, and Atorvastatin Calcium Tablets for 40 mg/d. Patients in the observation group were iv administered with Salvianolic Acid for Injection on the basis of control group, 0.13 g/d was performed. Patients in two groups were treated with infusion for 2 weeks. The NIHSS score, Barthel index score and cerebral infarction volume of the two groups were observed and compared. Results At 1 month and 3 months after treatment, the NIHSS score in the control group was significantly decreased. 2 weeks, 1 month and 3 months after treatment, NIHSS scores in the observation group were significantly reduced, and the difference before and after treatment in the same group was statistically significant (P<0.01). After treatment of 2 weeks, 1 month and 3 months, NIHSS score in the observation group was significantly lower than that of the control group, and the difference between the two groups was statistically significant (P<0.01). After treatment of 1 month and 3 months, Barthel scores in two groups were significantly increased, and the difference before and after treatment in the same group was statistically significant (P<0.01). And the Barthel score of the observation group was significantly higher than that of the control group, and the difference between the two groups was statistically significant (P<0.01). The cerebral infarction volume of the control group was significantly decreased at 3 months after treatment, while that of the observation group was significantly decreased at 1 month and 3 months after treatment, with statistically significant difference before and after treatment in the same group (P<0.01). After 1 month of treatment, the cerebral infarction volume of the observation group was significantly lower than that of the control group, and the difference between the two groups was statistically significant (P<0.01). Conclusion Salvianolic Acid for Injection in treatment of massive cerebral infarction patients can reduce the mortality of patients, has a certain impact on the quality of life, neurological function recovery and infarction volume of patients.

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