目的 观察注射用丹参多酚酸联合阿司匹林治疗急性大动脉粥样硬化型脑梗死临床疗效。方法 选取2017年2月-2018年1月在保定市第一中心医院就诊的急性大动脉粥样硬化型脑梗死患者202例作为研究对象，采用随机数字表法将患者分为对照组和观察组，每组各101例。对照组晨起空腹口服阿司匹林肠溶片，100 mg/次，1次/d。观察组在对照组治疗的基础上静脉输注注射用丹参多酚酸，0.13 g加入到生理盐水250 mL中稀释，1次/d。两组均治疗14 d。观察两组患者的临床疗效，同时比较两组治疗前后的美国国立卫生研究院卒中量表（NIHSS）评分、半乳糖凝集素-3（GLA-3）和白细胞介素-6（IL-6）水平。结果 治疗后，对照组和观察组的总有效率分别为63.4%和75.2%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，两组组NIHSS评分均显著下降（P<0.05），且观察组NIHSS评分显著低于对照组（P<0.05）。治疗后，两组的血清IL-6和GLA-3水平均显著下降（P<0.05），且观察组IL-6和GLA-3水平显著低于对照组（P<0.05）。结论 注射用丹参多酚酸联合阿司匹林治疗急性大动脉粥样硬化型脑梗死可促进患者神经功能恢复，改善患者的生活质量，降低炎性因子水平，且安全性较高，具有一定的临床应用价值。

Objective To observe the clinical effect of Salvianolic Acids for Injection combined with aspirin in treatment of acute atherosclerotic cerebral infarction. Methods A total of 202 patients with acute atherosclerotic cerebral infarction in the Baoding NO.1 Center Hospital from February 2017 to January 2018 were selected as the study subjects. Patients were divided into control group and observation group by random number table method, with 101 patients in each group. Patients in the control group were po administered with Aspirin Enteric-coated Tablets with empty stomach in the morning, 100 mg/time, once daily. Patients in the observation group were iv administered with Salvianolic Acids for Injection on the basis of control group, 0.13 g was added to 250 mL normal saline for dilution, once daily. Both groups were treated for 14 d. The clinical efficacy in two groups was observed, and the NIHSS score, GLA-3 and IL-6 levels of two groups before and after treatment were compared. Results After treatment, the total effective rate in the control group and the observation group was 63.4% and 75.2%, respectively, with statistically significant difference between the two groups (P<0.05). After treatment, NIHSS score in two groups were decreased significantly (P<0.05), and the NIHSS score in the observation group was significantly lower than that in the control group (P<0.05). After treatment, serum IL-6 and GLA-3 levels in two groups were significantly decreased (P<0.05), and IL-6 and GLA-3 levels in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Salvianolic Acids for Injection combined with aspirin in treatment of acute atherosclerotic cerebral infarction can promote the recovery of nerve function, improve the quality of life of the patients, reduce the level of inflammatory factors, and is relatively safe, which has a certain clinical application value.

R971

河北省医学科学研究重点课题（20181487）