[关键词]
[摘要]
目的 探讨注射用益气复脉(冻干)联合多巴胺/多巴酚丁胺治疗心源性休克的临床疗效。方法 选取郑州市中医院2018年1月-2019年12月收治的心源性休克患者120例为研究对象,采用随机数字法最终分为对照组(54例)和观察组(52例)。对照组患者在常规治疗的基础上给予大剂量盐酸多巴胺注射液5~20 μg/(kg·min)和盐酸多巴酚丁胺注射液5~15 μg/(kg·min)治疗。观察组在对照组治疗基础上静滴注射用益气复脉(冻干)2.6~5.2 g/次,加入5%葡萄糖注射液或0.9%氯化钠注射液250~500 mL中,1次/d。疗程为7~14 d。观察两组患者的临床疗效和不良反应情况,同时比较两组治疗前后的血压和尿量水平。结果 治疗后,观察组患者总有效率为94.2%,显著高于对照组的81.5%,两组比较差异有统计学意义(P<0.05)。治疗后,两组血压和尿量水平均明显改善,同组治疗前后比较差异有统计学意义(P<0.05、0.01),观察组的血压和尿量水平显著高于对照组,两组比较差异有统计学意义(P<0.05、0.01)。两组不良反应发生率差异无统计学意义。结论 注射用益气复脉(冻干)联合多巴胺/多巴酚丁胺治疗心源性休克患者具有一定的临床疗效,能够显著改善血压和尿量水平。
[Key word]
[Abstract]
Objective To investigate the clinical effect of injection of Yiqi Fumai Lyophilized Injection combined with dopamine/dobutamine in treatment of cardiogenic shock. Methods A total of 120 patients with cardiogenic shock admitted to Chinese Traditional Medicine Hospital of Zhengzhou from January 2018 to December 2019 were selected as study subjects, and finally divided into control group (54 cases) and observation group (52 cases) by random number method. Patients in the control group were treated with high-dose of Dopamine Hydrochloride Injection 5-20 μg/(kg·min) and Dobutamine Hydrochloride Injection 5-15 μg/(kg·min) on the basis of conventional treatment. Patients in the observation group were iv administered with Yiqi Fumai Lyophilized Injection on the basis of the control group, 2.6-5.2 g/time, adding 5% glucose injection or 0.9% sodium chloride injection into 250-500 mL, once daily. The course of treatment was 7-14 d. After treatment, the clinical efficacy and adverse reactions in two groups were observed, and the blood pressure and urine volume before and after treatment were compared.Results After treatment, the total effective rate in the observation group was 94.2%, which was significantly higher than 81.5% in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the blood pressure and urine volume in two groups were significantly improved, and the difference in the same group before and after treatment was statistically significant (P<0.05, 0.01). After treatment, the blood pressure and urine volume in the observation group was significantly higher than those in the control group, and the difference between two groups was statistically significant (P<0.05, 0.01). There was no statistically significant difference in the incidence of adverse reactions between the two groups. Conclusion Yiqi Fumai Lyophilized Injection combined with dopamine/dobutamine in treatment of cardiogenic shock has a certain clinical effect, can significantly improve the blood pressure and urine level.
[中图分类号]
R972
[基金项目]