心力衰竭是威胁人类健康的重大疾病之一，其病理机制复杂，中医药防治心衰具有显著特色。中医理论认为气阴两虚是心衰患者的主要证候之一，生脉散为益气养阴的代表方。目前根据生脉散研制的中成药包括注射用益气复脉、生脉注射液、生脉散、生脉饮、参麦注射液、生脉胶囊等，被广泛用于治疗心脑血管疾病。从生脉方改善线粒体功能、抑制心室重塑、减轻心肌细胞的炎性反应3个方面综述了生脉方治疗心衰的研究进展，以期为心衰的防治提供依据。

Heart failure is one of the major diseases that threaten human health, its pathological mechanism is complex, and the prevention and treatment of heart failure by Traditional Chinese Medicine (TCM) has significant advantages. The theories of TCM believes that deficiency of both Qi and Yin was one of the main syndromes of heart failure patients, and Shengmai San is a representative side of nourishing Qi and nourishing Yin. The current Chinese patent medicines developed based on Shengmai Powder include Yiqi Fumai for Injection, Shengmai Injection, Shengmai Powder, Shengmai Yin, Shenmai Injection, Shengmai Capsules and other products are widely used to treat cardiovascular and cerebrovascular diseases. This article reviews the research progress of Shengmai prescription in treating heart failure from three aspects:improving mitochondrial function, inhibiting ventricular remodeling, and reducing the inflammatory response of myocardial cells, in order to provide some clues and basis for the prevention and treatment of heart failure.

R285.6;R286.2

天津市科技重大专项与工程（18ZXXYSY00120）