[关键词]
[摘要]
目的 研究米格列醇联合格列吡嗪对2型糖尿病的疗效。方法 选择2016年1月—2019年1月荣县人民医院的98例2型糖尿病患者作为研究对象,用抽签法随机将患者分为对照组和观察组,每组各49例。对照组口服格列吡嗪片,起始的剂量为5 mg/d,最大的给药剂量为5~10 mg/次,2次/d。观察组在对照组的基础上服用米格列醇片,50 mg/次,3次/d。两组均治疗12周。观察两组患者的临床疗效,同时比较两组患者的血糖水平和不良反应发生情况。结果 治疗后,观察组治疗的总有效率为91.84%,明显高于对照组的73.47%(P<0.05)。两组治疗后的空腹血糖(FBG)、糖化血红蛋白(HbA1c)和餐后2 h血糖(2 h PG)均明显降低(P<0.05),且治疗后观察组血糖指标水平明显更低(P<0.05)。两组治疗期间不良反应的发生情况对比无统计学差异。结论 米格列醇联合格列吡嗪对2型糖尿病的疗效确切,能有效降低患者的血糖水平,安全有效,值得临床上应用。
[Key word]
[Abstract]
Objective To study the effect of miglitol combined with glipizide on type 2 diabetes mellitus. Methods A total of 98 patients with type 2 diabetes in Rongxian People's Hospital from January 2016 to January 2019 were selected as the research objects, and randomly divided into control group and observation group by lottery, with 49 patients in each group. Patients in the control group were po administered with Glipizide Tablets, the initial dose was 5 mg/d, and the maximum dose was 5-10 mg/d, twice daily. Patients in the observation group were po administered with Miglitol Tablets on the basis of the control group, 50 mg/time, three times daily. Both groups were treated for 12 weeks. After treatment, the clinical efficacy in two groups were observed, and the blood glucose level and adverse reactions were compared. Results After treatment, the total effective rate in the observation group was 91.84%, which was significantly higher than 73.47% in the control group (P<0.05). After treatment, the levels of FBG, HbA1c, and 2 h PG in two groups were significantly decreased (P<0.05), and the blood glucose index level in the observation group was significantly lower than those in the control group (P<0.05). There was no statistical difference in the occurrence of adverse reactions between the two groups during treatment. Conclusion Miglitol combined with glipizide has a definite therapeutic effect on type 2 diabetes, can effectively reduce the blood glucose level of patients, safe and effective, and is worthy of clinical application.
[中图分类号]
R977
[基金项目]