[关键词]
[摘要]
目的 探讨丹参注射液联合孟鲁司特钠对过敏性紫癜患儿免疫学指标和炎症因子的影响。方法 选取2016年11月—2018年11月安阳市中医院90例过敏性紫癜患儿为研究对象,根据就诊顺序均分为对照组(n=45)和观察组(n=45)。对照组在此基础上口服孟鲁司特钠咀嚼片,3~6岁:4 mg/次,1次/d,6~14岁:5 mg/次,1次/d。观察组患儿在对照组的基础上静脉滴注丹参注射液,0.5 mL/(kg·d),加入到5%葡萄糖溶液250 mL中,每日不超过20 mL。两组患者均连续治疗2周。观察两组患者的临床疗效,同时比较两组治疗前后的血清免疫学指标和炎症因子水平。结果 治疗后,观察组患儿治疗总有效率为95.56%,对照组总有效率为77.78%,两组比较差异性显著(P<0.05)。治疗后,两组患者免疫球蛋白(Ig)A、IgE、补体C3水平均较治疗前明显降低(P<0.05),且观察组IgA、IgE和补体C3水平显著低于对照组(P<0.05)。治疗后两组患者白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-26(IL-26)和肿瘤细胞坏死因子-α(TNF-α)水平较治疗前均显著降低(P<0.05),且观察组细胞因子水平显著低于对照组(P<0.05)。结论 丹参注射液联合孟鲁司特钠可有效减轻血液系统炎性反应,调节免疫,临床疗效显著,在过敏性紫癜患儿治疗中具有较高的应用价值。
[Key word]
[Abstract]
Objective To explore effect of Danshen Injection combined with montelukast sodium on serum immunological indicators and inflammatory factors in children with allergic purpura. Methods A total of 90 children with allergic purpura in Anyang Chinese Medicine Hospital from November 2016 to November 2018 were selected as research objects, and were divided into control group (n=45) and observation group (n=45) according to the order of treatment. Children in the control group po administered with Montelukast Sodium Chewable Tablets, 3 to 6 years old:4 mg/time, once daily, 6 to 14 years old:5 mg/time, once daily. Children in the observation group were iv administered with Danshen Injection on the basis of control group, 0.5 mL/(kg·d), which was added to 5% glucose solution 250 mL, no more than 20 mL per day. Patients in both groups were treated continuously for 2 weeks. The clinical efficacy in two groups was observed, and the serum immunological indexes and inflammatory factors before and after treatment were compared. Results After treatment, the total effective rate was 95.56% in the observation group and 77.78% in the control group, with significant difference between the two groups (P<0.05). After treatment, the levels of IgA, IgE, and C3 in two groups were significantly lower than those before treatment (P<0.05), and the levels of IgA, IgE, and C3 in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of IL-6, IL-8, IL-26, and TNF-α in two groups were significantly lower than those before treatment (P<0.05), and the levels of cytokines in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Danshen Injection combined with montelukast sodium can effectively reduce the inflammatory response, and regulate the immune system, with significant clinical efficacy, and has high application value in the treatment of children with allergic purpura.
[中图分类号]
R979.5
[基金项目]
安阳市重点科技计划项目(2015-95)