[关键词]
[摘要]
目的 探讨乌灵胶囊联合帕利哌酮对精神分裂症患者血清炎症因子和神经功能的影响。方法 选择2018年4月— 2019年10月在唐山市第五医院就诊的精神分裂症患者82例作为本实验对象,根据随机数字表法将所有患者分为对照组和观察组,每组各41例。对照组口服帕利哌酮缓释片,首次剂量为3 mg,1周后持续剂量6 mg,1次/d。观察组在对照组患者治疗的基础上口服乌灵胶囊,3粒/次,3次/d。两组患者连续治疗8周。对比两组的临床疗效,检测两组患者治疗前后血清因子水平,运用阳性和阴性症状量表(PANSS)评估患者的病情程度,不良反应症状量表(TESS)评估患者不良反应的发生状态。结果 治疗后,观察组的总有效率为87.80%,显著高于对照组的68.29%,两组差异有统计学意义(P<0.05)。治疗后,两组的白细胞介素-1β(IL-1β)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)均明显低于治疗前(P<0.05),且观察组的IL-1β、IL-17、TNF-α比对照组低,差异有统计学意义(P<0.05)。治疗后,两组的髓鞘碱性蛋白(MBP)、神经元特异性烯醇化酶(NSE)明显降低,脑源性神经营养因子(BDNF)明显升高(P<0.05);治疗后,观察组的MBP、NSE比对照组低,BDNF比对照组高,差异有统计学意义(P<0.05)。治疗后,两组PANSS评分明显低于治疗前(P<0.05);治疗后,观察组的PANSS评分比对照组低,差异有统计学意义(P<0.05)。两组主要不良反应的发生率与TESS评分比较,差异无统计学意义。结论 乌灵胶囊联合帕利哌酮可提高精神分裂症的疗效,减轻患者的临床症状,降低血清炎症因子的水平,保护神经功能,具有重要临床研究价值。
[Key word]
[Abstract]
Objective To investigate the effect of Wuling Capsules combined with paliperidone on serum inflammatory factors and nervous function in schizophrenics. Methods A total of 82 schizophrenics in Tangshan Fifth Hospital from April 2018 to October 2019 were randomly divided into control group and observation group, each group had 41 cases. Patients in the control group were po administered with Paliperidone Extended-Release Tablets, the first dose was 3 mg, and the continuous dose was 6 mg after 1 week, once daily. Patients in the observation group were po administered with Wuling Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 8 weeks. The clinical efficacy in two groups was compared, and the serum factor levels were detected before and after treatment. The severity of the patients' illness was assessed by using PANSS, and the occurrence status of the patients' adverse reactions was assessed by using the TESS. Results After treatment, the clinical efficacy in the observation group was 87.80%, which was higher than 68.29% of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of IL-1β, IL-17, and TNF-α in the two groups were significantly lower than those before treatment (P<0.05), and the levels of IL-1β, IL-17, and TNF-α in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05). After treatment, the levels of MBP and NSE in two groups were decreased significantly, but BDNF was increased (P<0.05).After treatment, MBP and NSE levels in the observation group were lower than those in the control group, but BDNF was higher than that in the control group, the difference was statistically significant (P<0.05). There was no statistically significant difference between two groups in the incidence of major adverse reactions and the TESS score. Conclusion Wuling Capsules combined with paliperidone can improve the efficacy of schizophrenia, reduce the clinical symptoms of patients, reduce the level of serum inflammatory factors, and protect the neurological function, has important clinical research value.
[中图分类号]
R971
[基金项目]
卫生部医药卫生科技项目(13010520111109);唐山市科技局计划项目(101302229)