[关键词]
[摘要]
临床前毒性试验或其他动物试验中动物出现疾病及死亡,是毒理学家和病理学家关心的重要问题之一。动物肺水肿临床症状表现复杂,结合病理学改变确定肺水肿的发生原因,对其临床前药物安全性评价尤为重要。针对临床前安全性评价实验中不同原因导致动物肺水肿进行阐述,对可能导致动物肺水肿的原因进行归类、分析,并对其动物的临床症状表现及病理学改变的特点作进一步的探讨,为临床前安全性评价结果提供更科学的判断标准。
[Key word]
[Abstract]
The occurrence of disease and death in preclinical toxicity test or other animal test is one of the important issues concerned by toxicologists and pathologists. The clinical symptoms of pulmonary edema in animals are complex. It is very important to evaluate the safety of drugs before clinical treatment to determine the cause of pulmonary edema combined with pathological changes. The causes of pulmonary edema in preclinical safety evaluation are been classified,discussed and analyzed in this paper and then clinical symptoms and pathological changes of experimental animals are been further discussed in order to provide more scientific judgment standards
[中图分类号]
[基金项目]