氧化苦参碱能抑制人胃癌MGC-803细胞移植瘤或人胰腺癌BxPC-3细胞移植瘤在裸鼠体内生长。体外实验发现氧化苦参碱能浓度相关地抑制人胃癌SGC-7901细胞、MGC803细胞、BGC823细胞、MKN-45细胞，人胰腺癌SW1990细胞，人食管癌Eca-109细胞增殖并诱导凋亡。体外实验发现氧化苦参碱能增强化疗药抗人胃癌SGC-7901细胞作用。临床上已试用于食管癌的治疗。

Oxymatrine inhibits the growth of transplantation tumor of human gastric carcinoma MGC-803 cells, or human pancreatic cancer BxPC-3 cells in nude mice. Oxymatrine inhibits proliferation and induces apoptosis in association with dosage on human gastric carcinoma SGC-7901 cells, MGC803 cells, BGC823 cells, MKN-45 cells, and human pancreatic cancer SW1990 cells, and human carcinoma of esophagus Eca109 cells, in vitro. Oxymatrine can promote the effects of chemotherapeutics against gastric carcinoma SGC-7901 cells in vitro. In clinic oxymatrine has been tried on the treatment of carcinoma of esophagus.

R285.5;R287.6