[关键词]
[摘要]
目的 探讨稳心颗粒联合苦碟子注射液治疗劳力型心绞痛的临床疗效。方法 选择2017年1月-2019年12月在酒泉市中医院治疗的160例劳力型心绞痛患者作为研究对象,所有患者按照随机数字表法分为观察组(n=80)和对照组(n=80)。对照组患者静脉滴注苦碟子注射液,40 mL/次,用0.9%氯化钠注射液稀释至250 mL,1次/d。观察组在对照组的基础上口服稳心颗粒,1袋/次,3次/d。14 d为1个疗程,两组均治疗1个疗程。治疗后,观察两组患者的临床疗效和证候疗效,同时比较两组患者心绞痛发作情况、治疗前后的超氧化物歧化酶(SOD)和丙二醛(MDA)水平。结果 治疗后,观察组和对照组总有效率分别为78.75%、60.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,观察组和对照组证侯疗效总有效率分别为81.25%、63.75%,两组证侯疗效总有效率比较差异具有统计学意义(P<0.05)。治疗后,观察组心绞痛发作次数、持续时间均显著少于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清SOD水平较治疗前明显上升,MDA水平明显下降,同组治疗前后比较差异具有统计学意义(P<0.05);且观察组SOD水平显著高于对照组,MDA水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 稳心颗粒联合苦碟子注射液治疗劳力型心绞痛,可提高氧化能力,清除氧自由基,减轻相关中医症侯,疗效好,安全性高,值得临床推广。
[Key word]
[Abstract]
Objective To explore the efficacy of Wenxin Granules combined with Kudiezi Injection in the treatment of exertional angina. Methods Patients (160 cases) with exertional angina from January 2017 to December 2019 in the Jiuquan Traditional Chinese Medicine Hospital were selected. According to the random number table method, patients were divided into the observation group (n=80) and the control group (n=80). Patients in the control group were iv administered with Kudiezi Injection, 40 mL/time, dilute to 250 mL with 0.9% sodium chloride injection, once daily. Patients in the observation group po administered with Wenxin Granules on the basis of control group, 1 bag/time, three times daily. 14 d was a course of treatment, both groups were treated for one course of treatment. After the treatment, the clinical effect and syndrome effect of two groups were observed, and the angina attack, the level of SOD and MDA before and after the treatment were compared. Results After treatment, the total effective rates of the observation group and the control group were 78.75% and 60.00%, respectively, the difference between the two groups was statistically significant (P<0.05). After treatment, the total effective rate of syndrome effect in the observation group and the control group were 81.25% and 63.75%, respectively, the difference between two groups was statistically significant (P<0.05). After treatment, the number and duration of angina attacks in the observation group were significantly less than those in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the serum SOD level in two groups was increased significantly, but the MDA level was decreased, and the difference before and after treatment in the same group was statistically significant (P<0.05). Moreover, SOD level in the observation group was significantly higher than that in the control group, and MDA level was significantly lower than that in the control group, and the difference between two groups was statistically significant (P<0.05). Conclusion Wenxin Granules combined with Kudiezi Injection in the treatment of exertional angina can improve the oxidation ability, remove oxygen free radicals, and relieve the symptoms of traditional Chinese medicine, with good efficacy and high safety, which was worthy of clinical promotion.
[中图分类号]
R972
[基金项目]
甘肃省中医药管理局科研课题(GZK-2017-66)