[关键词]
[摘要]
目的 探讨消渴清颗粒联合利格列汀治疗血糖控制不佳的2型糖尿病的临床疗效。方法 选择唐山市第八医院2018年4月-2019年11月收治的血糖控制不佳的2型糖尿病患者84例作为本实验对象,根据随机数字表法将患者分成对照组和观察组,每组各42例。对照组口服利格列汀片,5 mg/次,1次/d。观察组在对照组基础上温水冲服消渴清颗粒,6 g/次,3次/d。两组患者连续治疗16周。观察两组患者的临床疗效,同时比较两组治疗前后的血糖指标、体质量指数(BMI)、胰岛β细胞功能、细胞因子水平,录两组患者血糖达标时间。结果 观察组患者在治疗后的总有效率为95.24%,显著高于对照组的80.95%,差异有统计学意义(P<0.05)。治疗后,两组的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、BMI均明显降低,差异有统计学意义(P<0.05);治疗后,观察组的BMI比对照组低(P<0.05)。治疗后,两组的胰岛素(INS)、胰岛素β细胞功能指数(HOMA-β)明显升高,胰岛素抵抗指数(HOMA-IR)明显降低(P<0.05);治疗后,观察组的INS、HOMA-β比对照组高,HOMA-IR比对照组低,差异有统计学意义(P<0.05)。治疗后,两组的白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)显著降低,脂联素(APN)显著升高(P<0.05);治疗后,观察组的IL-1β、IL-6、TNF-α比对照组低,APN比对照组高,差异有统计学意义(P<0.05)。治疗后,观察组患者的血糖达标时间比对照组短,差异有统计学意义(P<0.05)。结论 消渴清颗粒联合利格列汀可提高血糖控制不佳的2型糖尿病的疗效,提高血糖控制效率,可能与调节炎症因子分泌,改善胰岛β细胞功能有关。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Xiaokeqing Granules combined with linagliptin in treatment of type 2 diabetes mellitus with poor blood glucose control. Methods A total of 84 patients with type 2 diabetes mellitus with poor blood glucose control in Tangshan Eighth Hospital from April 2018 to November 2019 were divided into control group and observation group, each group had 42 cases. Patients in the control group were po administered with Linagliptin Tablets, 5 mg/time, once daily. Patients in the observation group were treated with Xiaokeqing Granules on the basis of control group, 6 g/time, three times daily. Patients were treated for 16 weeks. The clinical efficacy in two groups were observed, the blood glucose index, BMI, β-cell function of insulin, and cytokine levels before and after treatment in two groups were compared, and the blood glucose standard time were recorded. Results The total effective rate of the observation group after treatment was 95.24%, which was significantly higher than 80.95% of the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of FBG, 2 h PG, HbA1c, and BMI were significantly decreased in two groups, and the difference was statistically significant (P<0.05). After treatment, BMI in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the INS and HOMA-β in two groups were significantly increased, but HOMA-IR were significantly decreased (P<0.05). After treatment, INS and HOMA-β in the observation group was significantly higher than those in the control group, but HOMA-IR was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of IL-1β, IL-6, and TNF-α in two groups were significantly decreased, but APN was increased (P<0.05). After treatment, the levels of IL-1β, IL-6, and TNF-α in the observation group were lower than those in the control group, but APN was higher than that in the control group, the difference was statistically significant (P<0.05). After treatment, the standard time of blood glucose in the observation group was shorter than that in the control group (P<0.05). Conclusion Xiaokeqing Granules combined with linagliptin can improve the efficacy of type 2 diabetes with poor blood glucose control, and improve the efficiency of blood glucose control, which may be related to regulating the secretion of inflammatory factors and improving the function of pancreatic islet cells.
[中图分类号]
R977
[基金项目]
河北省卫生和计划生育委员会科研基金项目(20160873)