[关键词]
[摘要]
目的 探讨骨炎灵片对急性骨髓炎患者的临床疗效及血清炎性指标的影响。方法 选取2018年1月-2019年6月于南阳市第二人民医院106例急性骨髓炎患者作为研究对象,将所有患者随机分为对照组和观察组,每组各53例。对照组给予行骨开窗减压和持续负压引流术等外科处理,同时给予敏感抗生素静脉滴注,注意补充水和电解质等综合治疗。观察组在对照组治疗基础上口服骨炎灵片,2.4 g/次,4次/d。两组疗程均为1个月。比较两组患者的临床疗效、创面愈合时间、住院时间、疼痛缓解50%时间及外周血白细胞(WBC)、中性粒细胞(N)、超敏C反应蛋白(hs-CRP)及血沉(ESR)水平的差异。结果 治疗后,对照组和观察组总有效率分别为81.13%和94.34%,差异具有统计学意义(P<0.05)。治疗后,观察组在创面愈合时间、住院时间和VAS评分降低50%时间均明显低于对照组,两组比较差异均具有统计学意义(P<0.05)。治疗后,两组患者外周血WBC、N、hs-CRP和ESR水平均显著降低,差异均具有统计学意义(P<0.05);与对照组相比,观察组外周血WBC、N、hs-CRP和ESR水平显著降低,差异均具有统计学意义(P<0.05)。结论 骨炎灵片治疗急性骨髓炎具有较好的临床疗效,能促进创面愈合,显著缓解机体疼痛和降低炎症指标,值得在临床中推广使用。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy and serum inflammatory factors levels of Guyanling Tablets in treatment of acute osteomyelitis.Methods A total of 106 patients with acute osteomyelitis in Second People's Hospital from January 2018 to June 2019 were selected. All the patients were randomly divided into control group and observation group, 53 cases in each group. The control group was given surgical treatment, such as decompression through bone fenestration and continuous negative pressure drainage, as well as intravenous infusion of sensitive antibiotics and comprehensive treatment including water and electrolyte supplementation. Patiens in the observation group were po administered with Guyanling Tablets on the basis of control group, 2.4 g/time, four times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy, wound healing time, hospital stay, VAS scores decreased 50% time, and the serum levels of WBC, neutrophil, hs-CRP, and ESR were compared.Results After treatment, the total effective rate in the control group and observation group were 81.13% and 94.34%, respectively, the difference is statistically significant (P<0.05). After treatment, the wound healing time, hospital stay, and VAS scores decreased 50% time in the observation group was significantly lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, WBC, N, hs-CRP, and ESR levels in peripheral blood of the two groups were significantly decreased, with statistically significant differences (P<0.05). After treatment, WBC, N, hs-CRP, and ESR levels in the peripheral blood of the observation group were significantly lower than those in the control group, with statistically significant differences (P<0.05). Conclusions Guyanling Tablets has a good clinical effect in treatment of acute osteomyelitis, can promote wound healing, significantly relieve body pain and reduce the inflammatory indicators, and is worthy of promotion in clinical use.
[中图分类号]
R287.2
[基金项目]